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Miao-Yan Fan^1,2, Qiao-Li Jiang¹, Meng-Yan Cui^2,3

¹Department of Gastroenterology, Jiading Branch of Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201803, China.

World journal of gastrointestinal surgery

|September 2, 2024

概括

胆囊切除术患者表现出改变的肠道微生物群,有增加的 Bacteroidetes 和特定的细菌丰度. 这可能为术后结直肠癌和腹治疗提供新的见解.

科学领域:

胃肠病学胃肠病学
微生物学微生物学
在瘤学瘤学.

背景情况:

胆囊切除术是一种常见的胆结石治疗方法.
胆囊切除术后的患者显示结直肠癌 (CRC) 发病率增加.
在这些患者中,改变的结肠微生物群和CRC之间的联系尚不清楚.

研究的目的:

为了研究肠道微生物群和胆囊切除术之间的相关性.
分析胆囊切除术后患者的粘膜微生物群变化.

主要方法:

对30名胆囊切除术后患者和28名对照患者进行了结肠镜检查.
16S-rRNA基因测序分析了细菌群落.
使用PICRUSt.t预测了功能性微生物的能力.

主要成果:

在PC患者中,Bacteroidetes的丰富性更高,Bacteroides,Parabacteroides和Bilophila的丰富性增加.
在60岁以上的PC患者中观察到明显的微生物群组成.
PC患者在脂聚糖生物合成和万科米辛抗生素生产途径中表现出丰富.

结论:

在胆囊切除术后的患者中,粘膜微生物群发生变化.
这些发现可能为治疗结直肠癌和胆囊切除术后腹提供新的视角.

关键词:

上升的结肠上升的结肠上升.结肠直肠癌是一种癌症.腹腹腹腹腹腹腹腹腹粘膜中的微生物群在胆囊切除术后.

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