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较高的瘤突变负担和PD-L1表达与血液性恶性瘤的生存时间较短相关

Ah-Reum Jeong¹, Aaron H Trando², Sean D Thomas³

¹Division of Blood and Marrow Transplantation, Department of Medicine, University of California San Diego, 3855 Health Sciences Drive, La Jolla, CA 92093-0658, USA.

Therapeutic advances in medical oncology

|September 2, 2024

概括

高瘤突变负担 (TMB) 和积极的编程死亡配体1 (PD-L1) 表达与血液恶性瘤的总生存时间较短有关. 这些发现强调TMB和PD-L1是这些癌症潜在的不良预后因素.

科学领域:

在瘤学瘤学.
血液学血液学血液学
免疫学免疫学免疫学

背景情况:

瘤突变负担 (TMB) 和编程死亡配体1 (PD-L1) 表达的预后意义在血液恶性瘤中仍未得到充分研究.
了解这些生物标志物对于预测患者的结果和指导血液癌症治疗策略至关重要.

研究的目的:

在患有血液性恶性瘤的患者中调查TMB和PD-1/PD-L1表达的特征和预后价值.
确定潜在的预测生物标志物,以此患者群体的整体存活.

主要方法:

一项现实研究涉及388名患有血液恶性瘤的患者,他们接受了下一代测序 (NGS) 进行TMB分析.
使用免疫组织化学评估PD-L1表达,按瘤比例得分 (TPS) 分类.
数据来自加利福尼亚大学圣地亚哥莫尔斯癌症中心 (2014-2018) 的电子病历.

主要成果:

最常见的诊断是B细胞非霍奇金淋巴瘤 (NHL) 和费城染色体阴性髓增殖性疾病.
TMB ≥4个突变/Mb和PD-L1阳性 (TPS ≥1%) 与较短的整体存活时间 (OS) 有显著关联.
较高的PD-L1表达 (≥50%) 显示出更明显的与减少的OS相关.

结论:

升高的TMB (≥4突变/Mb) 和积极的PD-L1表达 (TPS ≥1%) 被确定为血液恶性瘤的不良预后因素.
这些生物标志物与总生存率的降低相关,这表明它们在风险分层中的有用性.

关键词:

这是一种PD-1抑制剂.这是一种PD-L1抑制剂.检查点抑制剂检查点抑制剂血液学恶性瘤血液学恶性瘤免疫疗法免疫疗法瘤突变负担的突变负担

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