新型营养药物输送系统使用配制芝麻油,黄油和乳清素的大
Dheerendra Kumar Suman1, Kunal Pal2, Biswaranjan Mohanty3
1Department of Biotechnology, National Institute of Technology Andhra Pradesh, Tadepalligudem, Andhra Pradesh India.
Food science and biotechnology
|September 2, 2024
概括
这项研究探讨了使用pectin,芝麻油和kokum butter oleogels的新型比格尔对黄素的输送. 这些生物基配方有效调节口服库尔库释放.
科学领域:
- 食品科学与技术 食品科学与技术
- 材料科学 材料科学 材料科学
- 药物输送系统 药物输送系统
背景情况:
- 生物基食品正在获得可持续应用的吸引力.
- 黄素 (CRU) 具有治疗潜力,但需要有效的输送系统.
- 油为食品矩阵中的结构油提供了有希望的替代品.
研究的目的:
- 开发和描述用于黄素输送的新型大牛.
- 为了研究油脂凝含量对大油脂的特性和CRU释放的影响.
- 为了评估这些大的潜力,以调节口服黄素的管理.
主要方法:
- 使用芝麻油和黄油制备具有不同度 (10-50%) 的pectin-oleogel大饼.
- 使用tween 80进行乳化.
- 表面,物理,化学和物理化学性质的表征.
- 显微镜,FTIR和XRD分析.
- 在不同的pH条件下进行体外黄素释放研究.
主要成果:
- 显微镜检查证实了巨的双相结构.
- FTIR显示了结的变化,油凝含量增加.
- XRD证实了凝的无形性质.
- 增加的油凝含量降低了水分含量,并增加了阻抗因子.
- 黄素的释放在含有较高油脂凝的比格尔中减少,特别是在酸性pH下.
结论:
- 开发的比格尔显示出基于oleogel含量的调节性质.
- 这些大牛可以有效地控制黄素的释放,这表明口服输送的潜力.
- 这项研究强调了点-油凝大饼作为生物活性化合物的输送工具的实用性.
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