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新型Co (II) 和Zn (II) 诺基诺林复合物的合成,结构特征和计算研究,用于抗菌和抗氧化活性
Tadewos Damena1, Tegene Desalegn2, Sadhna Mathura3
1Department of Chemistry, Wachemo University, P.O. Box 667 Hossana, Ethiopia.
ACS omega
|September 2, 2024
概括
新的和复合物与素连接体显示强烈的抗菌活性对大肠杆菌和金黄色杆菌,与标准药物相比. 这些化合物也表现出显著的抗氧化特性,表明治疗潜力.
科学领域:
- 药用化学 医学化学
- 无机化学 无机化学
- 生物化学 生物化学
背景情况:
- 在生物医学研究中,异环联体,特别是类衍生物,越来越重要.
- oline衍生物的过渡金属复合物作为开发新生物活性分子的有希望的支架.
研究的目的:
- 合成和表征新的 (II) 和 (II) 复合物,其中含有双酸类衍生物合物.
- 评估这些复合物的生物应用,重点关注抗菌活性和抗氧化特性.
主要方法:
- 通过光谱学方法 (NMR,FTIR,UV-vis,光,质谱学),热重力测量和元素分析进行合成和结构性表征.
- 生物评估包括体外抗菌试验 (扩散,阿加稀释),对抗细菌酶的分子对接 (DNA旋转酶,二叶酸还原酶,氨酸-tRNA合成酶) 和抗氧化活性试验 (DPPH基因清理).
- 使用密度函数理论 (DFT) 和时间依赖 (TD) -DFT的计算分析.
主要成果:
- 合成的Zn (II) 和Co (II) 复合物得到了充分的描述.
- 复合物对大肠杆菌 (MIC 0.20μg/mL) 具有强烈的活性,对DNA回旋酶和二叶酸减少酶具有很高的结合亲和力.
- 复合物对黄金色细菌 (MIC 2.4μg/mL) 具有显著的活性,并与铁-tRNA合成酶强度结合,两种复合物都表现出显著的抗氧化活性.
结论:
- 新型基于素的Zn (II) 和Co (II) 复合物具有显著的抗菌和抗氧化特性.
- 这些发现突显了这些金属复合物的治疗潜力,这些金属复合物作为抗微生物和抗氧化剂.
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