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Updated: Jun 14, 2025

A New Straightforward Method for Lipophilicity logP Measurement using 19F NMR Spectroscopy
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奇数顺序导数在里埃变换中的应用 核磁共振光谱学朝量化解卷化方向的应用

Shu-Ping Chen1,2, Sandra M Taylor3, Sai Huang2

  • 1Nexus Scitech Centre of Canada, 17 White Oak Crescent, Richmond Hill, Ontario L4B 3R7, Canada.

ACS omega
|September 2, 2024
PubMed
概括

奇数顺序导数有效地解构了富里埃变换 (FT) 核磁共振 (NMR) 光谱中的重叠峰值. 这种方法提供了更好的动态范围和对噪声和采样率的稳定性,用于准确的光谱分析.

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The probability of having two carbon-13 atoms next to each other is negligible because of the low natural abundance of carbon-13. Consequently, peak splitting due to carbon-carbon spin-spin coupling is not observed in spectra. However, protons up to three sigma bonds away split the carbon signal according to the n+1 rule, resulting in complicated spectra.
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