根据乳腺癌亚型的临床表现和生存率的种族/民族差异
Vutha Nhim1,2, Alfonso E Bencomo-Alvarez3,4, Luis Alvarado5
1Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, TX, United States.
Frontiers in oncology
|September 2, 2024
概括
西班牙裔种族影响乳腺癌存活率不同,根据出生地和亚型. 美国出生的西班牙裔女性面临TNBC的更高风险,而Luminal A乳腺癌显示西班牙裔患者的死亡率增加,无论其来源如何.
科学领域:
- 在瘤学瘤学.
- 健康差距 研究 研究 研究 研究
- 流行病学 流行病学
背景情况:
- 乳腺癌 (BC) 在种族和种族群体之间表现出不同的影响,导致临床表现和结果的差异.
- 西班牙裔种族对BC结果的具体影响,考虑到地理位置和接近美墨边境,仍然不清楚.
- 假设种族/种族对BC结果的影响因不同BC亚型的地理位置和原产国而异.
研究的目的:
- 调查西班牙裔种族,地理来源,居住地和不同亚型的乳腺癌结果之间的关联.
- 为了确定是否靠近美墨边境影响了西班牙裔人口中乳腺癌存活率.
- 阐明种族,种族,出生地和居住地的复杂相互作用对乳腺癌存活率的影响.
主要方法:
- 来自德克萨斯州癌症登记处的乳腺癌数据分析,按种族/种族和出生地分层.
- 包括BC亚型:Luminal A,Luminal B,人体表皮生长因子受体2 (HER2) 阳性和三阴性乳腺癌 (TNBC).
- 利用考克斯回归来分析种族/种族,出生地和居住地对整体存活率 (OS) 的原始和调整后的影响,控制年龄,治疗和并发性疾病.
主要成果:
- 与非西班牙裔白人 (NHW) 患者相比,西班牙裔和非西班牙裔黑人 (NHB) 患者在所有亚型中都在较年轻时被诊断出BC.
- 西班牙裔患者在Luminal A BC中表现出更高的死亡风险,无论出生地;美国出生的西班牙裔患者在TNBC中显示出更高的风险.
- 在Luminal A和HER2亚型中,NHB患者的死亡风险较高;边境居住对OS的影响最小,根据亚型和年龄的结果各不相同.
结论:
- 种族/种族,地理出生地和居住地是乳腺癌存活率的重要预测因素.
- 诸如移民,同文化化和获得医疗保健等因素可能是观察到的结果差异的基础.
- 需要进一步的研究,以解决不同人群中乳腺癌存活率的复杂决定因素.
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