工程血管化器官在芯片上:战略,进展和未来的前景
Zhangjie Li1, Dingyuan Yu1, Chenyang Zhou1
1Department of Micro/Nano Electronics, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Biomaterials translational
|September 2, 2024
概括
机器人芯片技术通过模仿人类器官生理学来推进药物查. 本次审查的重点是开发血管化的芯片上的有机体模型,以改善体外疾病建模和药物开发.
科学领域:
- 生物技术是生物技术.
- 组织工程是组织工程.
- 微流体学 微流体学
背景情况:
- 芯片上的有机体平台集成有机体和微流体用于体外人体器官建模.
- 这些系统模拟生理微环境,提供动态和灵活的生物环境.
- 一个关键的限制是功能性血管系统的缺失,阻碍了长期培养和全面建模.
研究的目的:
- 审查开发血管化器官在芯片上的模型的研究进展.
- 讨论实现体外血管化的方法.
- 突出血管化有机体的进步,以改善药物开发和个性化医疗.
主要方法:
- 审查关于微型制造和组织工程技术的当前文献.
- 对有机体的体外血管化方法的分析.
- 检查创建血管化的有机体系统的进展.
主要成果:
- 在开发血管化的芯片上的有机体模型方面取得了重大进展.
- 目前正在探索和完善各种体外血管化策略.
- 血管化对于提高这些平台的生理相关性和实用性至关重要.
结论:
- 血管化器官在芯片上的平台对药物开发和个性化医学有着巨大的前景.
- 需要进一步的研究来构建功能齐全的血管化系统.
- 这一综述可以作为该领域未来发展的参考.
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