肝功能相关指标和胆结石疾病风险 - 一项多中心研究和系统审查和元分析
Shiyi Li1, Pei Zhu2, Fangyuan Chen3
1West China School of Public Health Sichuan University, South Renmin Road, Wuhou District, Chengdu 610041, China.
Gastroenterology research and practice
|September 2, 2024
概括
像AST和ALT这样的肝功能测试与胆结石疾病 (GSD) 风险有关. 某些肝酶和蛋白质的水平升高可能表明GSD风险较高,有助于早期识别.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 胃肠病学 胃肠病学
- 流行病学 流行病学
背景情况:
- 胆结石病 (GSD) 是一种具有多因素病因的普遍疾病.
- 了解肝功能在GSD发育中的作用对于风险分层和预防至关重要.
研究的目的:
- 调查各种肝功能指标与患胆结石病的风险之间的关联.
- 通过元分析和独立的队列研究来验证发现.
主要方法:
- 分析了来自中国多中心体检队列 (CMPEC) 的数据,其中包括369,931名受试者.
- 在2021年7月之前对28篇出版物的系统审查和元分析.
- 使用英国生物银行 (UKB) 队列验证.
主要成果:
- 在阿斯巴氨基转移酶 (AST),氨基转移酶 (ALT),性酸酶 (ALP),总蛋白质 (TP) 和低白蛋白 (ALB) 与GSD风险之间发现了积极的关联.
- 与健康对照人相比,患有GSD的个体表现出较高的AST,ALT,胺转移酶 (GGT),总 bilirubin (TBil),全球蛋白 (G) 和ALP,以及较低的TP和ALB水平.
- 在UKB队列中证实了ALP和GSD风险之间的关联.
结论:
- 肝功能指标与胆结石疾病风险显著相关.
- 这些发现可能有助于理解GSD病因学.
- 这项研究为临床医生提供了一个基础,以确定高风险的个人GSD.
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