梅莉亚亚亚泽达拉克 (Melia azedarach) 的物理化学和乳化特性
Kofi Acheampong Asamoa Mensa1, Noble Kuntworbe1, Yaa Asantewaa Osei1
1Department of Pharmaceutics Faculty of Pharmacy and Pharmaceutical Sciences Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Scientifica
|September 2, 2024
概括
梅莉亚亚青 (MA) 表现出优异的乳化特性,与秋可比,使其成为药物输送系统的有希望的辅助剂. 这项研究突出了MA的口香糖.
科学领域:
- 制药科学 制药科学
- 材料科学 材料科学 材料科学
背景情况:
- 自然存在的水友性合物是制药配方中至关重要的辅助成分.
- 这些合物具有多种作用,包括涂层,分解,结合和乳液稳定.
研究的目的:
- 为了研究从Melia azedarach (MA) 提取的口香糖的物理化学和乳化特性.
- 为了评估MA作为石油在水乳液中的潜在乳化剂.
主要方法:
- 在MA中提取,净化,并进行物理化学,微生物和近距离分析.
- 橄油乳液是使用不同度 (5-15%w/v) 的MA膠制成的.
- 乳液稳定性通过zeta潜力,化指数,滴滴大小以及对pH,温度和电解质变化的反应进行评估.
主要成果:
- 纯化MA的产量为68.3%w/w,具有低湿度和良好的膨胀性,没有检测到重金属.
- 含有15%w/vMA的乳液显示出小的平均滴滴大小 (2.791 ± 0.694 μm) 和高的泽塔电位 (-32.867 mV),与木偶相似.
- 马氏体乳液表现出增强的粘度,乳液容量和稳定性,与木乳液相比,乳脂指数较低.
结论:
- 梅莉亚青糖具有显著的乳化能力,度为15%w/v.
- 马氏体是一种可行的,潜在的优质替代品,可用于药物应用中稳定乳液.
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