对癌症缓解症的动物模型进行全面审查:对翻译研究的影响
Li Li1,2, Junaid Wazir1,2, Zhiqiang Huang1,2
1State Key Laboratory of Analytical Chemistry for Life Science, Medical School, Nanjing University, Nanjing, Jiangsu 210093, China.
Genes & diseases
|September 2, 2024
概括
癌症缓解症的临床前模型对于推进治疗至关重要. 本次审查评估了当前的模型,强调了它们的局限性和需要更好的翻译研究工具.
科学领域:
- 在瘤学瘤学.
- 翻译医学是一种翻译医学.
- 动物模型 动物模型
背景情况:
- 癌症缓解症是一种渐进式减肥的复杂综合征,对营养支持没有反应.
- 将临床前发现转化为癌症缓解症的临床实践仍然是一个重大挑战.
- 现有的临床前模型往往无法准确地复制癌症缓冲症的临床复杂性.
研究的目的:
- 审查和总结常用的癌症缓解症临床前模型.
- 评估当前癌症缓解症模型的特点和局限性.
- 为改善癌症缓解症的翻译医学研究提供见解.
主要方法:
- 对癌症缓解症临床前模型的现有文献进行系统审查.
- 各种模型类型的分类和分析,包括异构,异种移植,基因工程,药物诱导,传统中医,斑马鱼,Drosophila和细胞模型.
- 评估模型的相关性和临床翻译的局限性.
主要成果:
- 确定了关键的临床前模型:异种/异种移植,基因工程小鼠模型 (GEMMs),化疗诱导,中医药欠缺,斑马鱼/多索菲拉和细胞模型.
- 突出了临床前模型和人类临床条件之间的差异.
- 强调需要提高模型忠实度,以促进临床翻译.
结论:
- 对于有效的翻译研究来说,全面了解当前的癌症缓解症模型是必不可少的.
- 需要进一步开发和验证临床前模型,以弥合基础研究和临床应用之间的差距.
- 这一综述为选择和开发更好的癌症缓解症研究和治疗工具提供了基础.
相关概念视频
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Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
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