在口服后,fluralaner在不同食肉动物物种的便消除
Philippe Jacques Berny1, Dalil Belhadj1, Bernadette España1
1UR-ICE Vetagro Sup, Lyon, France.
Frontiers in veterinary science
|September 2, 2024
概括
一种新的杀虫剂Fluralaner在动物园的食肉动物便中排泄数周到数月. 这种长时间的便排泄fluralaner (异zoline杀虫剂) 引发了对非目标物种的环境问题.
科学领域:
- 兽医药理学 兽医药理学
- 寄生虫学的寄生虫学
- 野生动物健康 野生动物健康
背景情况:
- 弗洛拉拉纳是一种新型的异黄类寄生虫杀药,广泛用于伴侣动物的跳和控制.
- 对动物园的食肉动物来说,对外寄生虫的控制至关重要,但缺乏特定的批准产品.
- 弗洛拉拉纳主要在便中未经改变 (> 90%) 排泄.
研究的目的:
- 为了确定fluralaner在动物园食肉动物中的药理动力学概况.
- 评估fluralaner在这些动物的长期便清除期.
- 调查由于排泄的残留物对非目标物种的潜在环境影响.
主要方法:
- 动物园的食肉动物被口服了fluralaner,用全度方程调整剂量.
- 便样本被采集了长达三个月,以建立便消除曲线.
- 便样本中的fluralaner度使用经过验证的液体染色学-并联质谱法 (LC-MSMS) 技术量化.
主要成果:
- 在大多数动物园食肉动物的便中检测到Fluralaner数周到几个月.
- 在狮子中,在注射后89天,在便样本中仍然可以检测到fluralaner.
- 该研究表明,在动物园的食肉动物中,fluralaner的清除期延长了.
结论:
- 这项研究提供了第一个证据,证明了动物园食肉动物中扩展的fluralaner消除.
- 长时间的排泄期要求进一步调查活性残留物的环境风险.
- 对非目标关节动物和伴侣动物 (狗,猫) 的潜在影响需要进一步研究.
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