在肝脏疾病中准蛋白氨酸酸酶的治疗潜力
Ao Wang1,2, Yi Zhang1, Xinting Lv1
1Department of Pharmacy and Institute of Inflammation, Zhejiang Provincial Affiliated People's Hospital, Hangzhou Medical College, Hangzhou 310014, China.
Acta pharmaceutica Sinica. B
|September 2, 2024
概括
蛋白氨酸酸酶 (PTPs) 对肝脏健康和疾病至关重要. 这次审查强调了PTPs.
科学领域:
- 生物化学和分子生物学
- 细胞生理学 细胞生理学
- 肝病学 肝病学是一种肝病学.
背景情况:
- 蛋白质氨酸酸化,由蛋白质氨酸激酶 (PTKs) 和蛋白质氨酸酸酶 (PTPs) 调节,对于细胞平衡至关重要.
- PTPs在维持细胞生理学方面发挥着不可或缺的作用,并且在肝脏生理和病理过程中至关重要.
- PTPs的失调与慢性肝病 (CLD),肝细胞癌 (HCC) 和肝损伤等肝病有关.
研究的目的:
- 在肝脏疾病的背景下,提供PTP的功能和机制的全面审查.
- 突出临床意义上的PTP成员参与肝病的发展和进展.
- 总结关于用于治疗肝病的PTP向化合物的当前研究及其临床潜力.
主要方法:
- 对肝脏生理学和病理学中PTPs现有研究的文献综述.
- 分析PTP在各种肝病的发展和进展中的作用.
- 评估目前针对肝病治疗中PTP的治疗策略.
主要成果:
- PTPs是细胞过程的关键调节者,并与多种肝脏病理有关.
- 几种PTP已经成为肝病的临床重要标.
- 针对PTP的化合物显示出作为肝脏疾病新型治疗剂的新兴潜力.
结论:
- PTP对于肝功能和疾病的发病过程至关重要,这使得它们成为重要的治疗点.
- 针对PTP提供了一个有前途的途径,用于开发肝脏疾病的新疗法.
- 对PTP向化合物的进一步研究是有必要的,以推进肝病学中的临床应用.
相关概念视频
02:54Protein Kinases and Phosphatases
13.1K
Proteins undergo chemical modifications that trigger changes in the charge, structure, and conformation of the proteins. Phosphorylation, acetylation, glycosylation, nitrosylation, ubiquitination, lipidation, methylation, and proteolysis are various protein modifications that regulate protein activity. Such modifications are usually enzyme-driven.
Protein kinases
Many proteins in the cell are regulated by phosphorylation, the addition of a phosphate group. A family of enzymes called kinases...
Protein kinases
Many proteins in the cell are regulated by phosphorylation, the addition of a phosphate group. A family of enzymes called kinases...
13.1K
01:27Transducer Mechanism: Enzyme-Linked Receptors
2.4K
Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
Major types that are helpful drug targets include:
2.4K
01:26Treatment for Pulmonary Arterial Hypertension: Receptor Tyrosine Kinase Inhibitors and Calcium Channel Blockers
147
Receptor tyrosine kinase inhibitors (TKIs) and calcium channel blockers (CCBs) are two critical categories of drugs employed in the treatment of pulmonary artery hypertension (PAH). PAH is a disease that causes high blood pressure in the pulmonary arteries, resulting in chest pain, fatigue, and shortness of breath.
TKIs, such as imatinib (Gleevec), are particularly effective in tackling the growth and mitogenic factors that become upregulated in PAH patients. These factors contribute to the...
TKIs, such as imatinib (Gleevec), are particularly effective in tackling the growth and mitogenic factors that become upregulated in PAH patients. These factors contribute to the...
147
02:57Targeted Cancer Therapies
7.5K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.5K
01:02Phosphorylation
50.1K
The addition or removal of phosphate groups from proteins is the most common chemical modification that regulates cellular processes. These modifications can affect the structure, activity, stability, and localization of proteins within cells as well as their interactions with other proteins.
During phosphorylation, protein kinases transfer the terminal phosphate group of ATP to specific amino acid side chains of substrate proteins. Serine, threonine, and tyrosine are the most commonly...
During phosphorylation, protein kinases transfer the terminal phosphate group of ATP to specific amino acid side chains of substrate proteins. Serine, threonine, and tyrosine are the most commonly...
50.1K
01:26Receptor Tyrosine Kinases
12.5K
Receptor tyrosine kinases or RTKs are membrane-bound receptors that phosphorylate specific tyrosine on protein substrates. RTKs regulate cellular growth, differentiation, survival, and migration. They contain an extracellular ligand binding domain, a transmembrane domain, and a cytosolic tail with intrinsic kinase activity. Several extracellular signaling molecules activate RTKs in one or more ways and relay the signal downstream. Ligands such as platelet-derived growth factor (PDGF) or...
12.5K