增长激素分泌的垂体腺瘤对边缘系统的影响及其与认知障碍的相关性
Chengbin Duan1, Mengqi Wang2, Shun Yao1
1Center for Pituitary Surgery, Department of Neurosurgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China.
Heliyon
|September 2, 2024
概括
增长激素分泌 pituitary adenoma (GHPAs) 患者表现出边缘灰质体积的减少,特别是在海马体和边缘皮层. 这种减少与认知功能受损相关,特别是轻度认知障碍.
科学领域:
- 神经内分泌学神经内分泌学
- 神经成像是一种神经成像.
- 认知神经科学 认知神经科学
背景情况:
- 垂体腺瘤是影响激素调节的常见瘤.
- 增长激素分泌的垂体腺瘤 (GHPAs) 可以导致壮并影响各种身体系统.
- 对于GHPAs对边缘系统结构和认知功能的影响仍然不完全理解.
研究的目的:
- 在患有GHPA的患者中量化评估边缘系统灰质体积.
- 为了研究边缘灰质体积和GHPA患者的认知功能之间的相关性.
- 为了比较GHPA和非功能性垂体腺瘤 (NFPA) 患者之间的边缘灰质体积和认知功能.
主要方法:
- 对91名垂体腺瘤患者 (48名GHPA,43名NFPA) 的回顾性分析.
- 使用T1WI-MPRAGE进行细胞MRI,用于使用Brainsite平台进行体积分析.
- 使用蒙特利尔认知评估 (MoCA) 和迷你精神状态检查 (MMSE) 进行认知功能评估.
主要成果:
- 与NFPA患者相比,GHPA患者的灰质总体体积显著增加.
- 相对的边缘系统灰质体积在GHPA患者中明显较低.
- 在MoCA上,GHPA患者的得分较低,相对边缘体积和MoCA得分之间存在显著的相关性.
- 主导半球的海马和边缘皮层体积与轻度认知障碍有显著的相关性.
结论:
- GHPA与边缘灰质体积的相对减少有关,特别是在主导半球的海马体和边缘皮层.
- 边缘系统的这种结构变化与GHPA患者的轻度认知障碍有关.
- 这些发现突出了GHPAs的神经解剖学和认知后果.
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