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侧向外关节度研究的统计脆弱性:一个系统的审查
Rory Byrne1, Benjamin Ahn1, Leon Zhao1
1Department of Orthopaedic Surgery, Alpert Medical School of Brown University, Providence, Rhode Island, USA.
Orthopaedic journal of sports medicine
|September 2, 2024
概括
对前十字带重建 (ACLR) 的侧侧额外关节延展 (LET) 的研究显示了统计上的脆弱性. 对于初级ACLR的LET研究比对修订ACLR的研究更为脆弱,这表明需要进行更多的研究.
科学领域:
- 整形外科手术 整形外科手术
- 生物机械研究的研究.
- 临床研究中的统计分析.
背景情况:
- 由于结果的逆转,统计学意义 (P < .05) 可能是不可靠的.
- 骨科文献越来越多地使用脆弱度指标,如脆弱指数 (FI) 和脆弱率 (FQ).
- 侧侧额外关节切术 (LET) 正在引起人们对增强前十字带重建 (ACLR) 的兴趣.
研究的目的:
- 评估随机对照试验 (RCT) 的统计脆弱性和对ACLR的LET的比较研究.
- 测试LET研究结果在统计学上脆弱的假设.
- 评估LET的脆弱性指标在初级和修订ACLR之间.
主要方法:
- 对LET作为ACLR (2000-2022) 的辅助对比研究和RCT的系统审查.
- 对二分和连续结果的分析.
- 计算脆弱性指数 (FI),连续FI (CFI),脆弱率 (FQ) 和连续FQ (CFQ).
主要成果:
- 包括29项研究 (9项RCT,20项比较研究);79.3%的研究是在2020年之后发表的.
- 中位FI为9.0,中位FQ为0.1;中位CFI为7.8,中位CFQ为0.12.
- 对LET与修订ACLR的研究显示,FQ (0.117) 和CFQ (0.113) 比对初级ACLR (0.042和0.095) 的研究更高.
结论:
- 对于初级ACLR的LET研究显示出比对修订ACLR的LET研究更大的统计脆弱性.
- 需要进一步的研究来澄清LET在初级ACLR中的指示.
- 整形医学研究应该结合脆弱度指标与传统的P值.
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