乳头瘤病毒感染和男性不孕症:一个系统的审查和元分析
Andrea Garolla1, Silvia Mereu1, Damiano Pizzol2
1Unit of Andrology and Reproductive Medicine, Department of Medicine University of Padova Padova Italy.
Health science reports
|September 2, 2024
概括
男人感染人类乳头瘤病毒 (HPV) 与精子质量差,包括形态和运动能力降低有关. 这会影响男性的生育能力,增加流产的风险.
科学领域:
- 生殖医学 生殖医学
- 传染性疾病 传染性疾病
- 男人的健康 男人的健康
背景情况:
- 越来越多的证据将人类乳头瘤病毒 (HPV) 感染与男性的不良生殖结果联系起来.
- HPV与精液参数受损,囊胚细胞亡增加和植入率降低有关.
- 这种感染还与更高的流产率和自发早产率相关.
研究的目的:
- 系统地审查和元分析HPV感染和精子参数之间的关联.
- 评估HPV对男性生育能力和怀孕结果的影响.
主要方法:
- 在多个数据库 (PubMed/MEDLINE,Scopus,Embase,Web of Science,CINHAL,PsycINFO,ERIC) 进行了系统的搜索.
- 包括来自25项涉及6942名患者的研究的数据.
- 对相关参数的平均数据和标准偏差进行了元分析.
主要成果:
- 精子形态 (SMD = -0.52,p = 0.001) 和运动性 (SMD = -0.82,p < 0.001) 在HPV阳性男性中明显较低.
- 没有发现精子体积,度或pH值的显著差异.
- 其他研究表明,HPV与精子参数受损,生育能力降低和妊娠损失风险增加之间存在很强的关联.
结论:
- 感染HPV与精子参数受损和男性生育能力下降有关.
- 这些发现表明,HPV增加了流产的风险和再次感染的可能性.
- 这凸显了在男性生殖健康管理中解决HPV的重要性.
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