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光体子对雌二醇酸诱导的TEC亡和损害双阳性胸细胞发育的保护作用

Jihong Yang^1,2,3, Haitao Pan², Mengyao Wang²

¹College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China.

Frontiers in pharmacology

|September 2, 2024

概括

根oderma lucidum子 (GLS) 通过保护甲状腺上皮细胞和增强CD4+ T细胞输出来减轻甲状腺缩. 运动皮体去除的GLS (RGLS) 特别促进T细胞受体重组和iNKT细胞发育.

科学领域:

免疫学免疫学免疫学
细胞生物学细胞生物学
药理学药理学是指药理学的学科.

背景情况:

胸膜缩是免疫衰老的标志,导致T细胞发育缺陷.
众所周知,Ganoderma lucidum子 (GLS) 能够调节T细胞的发育,但其机制尚不清楚.
雌二醇酸 (EB) 诱导胸膜缩,为研究T细胞再生提供了一个模型.

研究的目的:

研究GLS调节T细胞发育的机制,在EB诱导的胸膜缩的小鼠模型中.
评估GLS在缓解胸膜衰老和T细胞功能障碍方面的治疗潜力.

主要方法:

构建一个EB诱导的胸膜缩小鼠模型.
施用GLS并评估其对胸膜结构和T细胞群的影响.
应用多组学技术来阐明分子机制.
分析T细胞受体 (TCR) 的重新排列,iNKT细胞分化,以及胸细胞-mTECs相互作用.

主要成果:

GLS减弱了胸膜上皮细胞 (TEC) 亡和增加了CD4+ T细胞输出.
运动皮去除的GLS (RGLS) 增强了TCR V-J重排频率和效率.
通过CD1d通路,RGLS促进了双阳性 (DP) 到CD4+不变的自然杀手T (iNKT) 细胞分化.
RGLS抑制了特定基因上调,减少了mTECs对CD4+T细胞的清除,从而增强了T细胞输出.

结论:

通过保护TEC和改善DP胸细胞的发育,RGLS有效地减轻EB诱导的胸膜缩.
GLS,特别是RGLS,显示出作为T细胞再生的免疫调节剂的潜力.
这些发现为使用GLS治疗与年龄相关的免疫衰退提供了机制性的见解.

关键词:

甘白光子子子在T细胞发育过程中,在T细胞受体基因重组过程中,T细胞受体基因重组.蛋白质组学蛋白质组学一个单细胞RNA测序.胸腺缩症胸腺缩症

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