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炎症饮食,肠道微生物群和神经感官听力损失:一个横截面和门德尔随机化研究

Yixuan Wang¹, Jiayi Nie², Kaige Yan³

¹Department of Otolaryngology Head and Neck Surgery, Shaanxi Provincial People's Hospital, Xi'an, China.

Frontiers in nutrition

|September 2, 2024

概括

炎症饮食可能会增加神经感官听力损失 (SNHL) 的风险. 摄入鱼类可能会减少SNHL,突出显示潜在的肠内耳连接.

科学领域:

营养科学营养科学
耳鼻喉科耳鼻喉科耳鼻喉科
微生物组研究微生物组研究

背景情况:

炎症饮食与慢性炎症和肠道失调有关.
饮食模式和感觉神经听力损失 (SNHL) 之间的联系尚未得到充分理解.
肠道微生物群的改变可能会影响全身健康,包括听觉功能.

研究的目的:

调查饮食偏好之间的关联,使用饮食炎症指数 (DII) 和SNHL.
探索各种饮食因素,肠道微生物群和SNHL之间的因果关系.
确定影响SNHL风险的特定饮食成分和微生物物种.

主要方法:

利用国家健康和营养检查调查 (NHANES) 的数据进行DII和SNHL评估.
采用孟德尔随机化 (MR) 分析34种饮食偏好,211种肠道微生物群和SNHL之间的因果关系.
应用平滑曲线适配来确定剂量反应关系.

主要成果:

增加的DII分数超过5.15与较高的SNHL风险相关.
饮食中摄入油性和非油性鱼类与SNHL风险降低有关.
六种特定的肠道微生物物种与SNHL有显著的因果关系.

结论:

促炎症饮食可能会增加患SNHL的风险.
这些发现表明潜在的肠内耳轴,由饮食和肠道微生物群介导.
鱼类消费似乎对SNHL有保护作用,可能是通过调节肠道微生物群.

关键词:

门德尔的随机化尼汉斯 (NHANES) 是一个名人.我们的肠道微生物群.炎症性饮食炎症性饮食感应神经神经听力损失

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