在没有糖尿病的患者中,来自塞马格卢提德的优甘血糖酸性酸症
Nikhil Sood1, Ojas Bansal2, Rohini Garg3
1Department of Hospital Medicine, Banner Health, Gilbert, AZ 85234, USA.
JCEM case reports
|September 2, 2024
概括
尤格莱西米酸性酸症是一种严重的疾病,即使在非糖尿病患者中,也可能发生在塞马格卢提德的治疗中. 早期识别和治疗这种不良事件对于患者的安全至关重要.
科学领域:
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
- 内部医学 内部医学
背景情况:
- 优糖性酸性 (EKA) 是一种与糖尿病患者的SGLT-2抑制剂相关的已知的不良事件.
- 有限的数据存在于EKA发生与葡萄糖类-1 (GLP-1) 受体激活剂,如semaglutide.
研究的目的:
- 报告一个非糖尿病患者使用西马格卢提德减肥的euglycemic ketoacidosis病例.
- 突出EGK与GLP-1受体激动剂的潜力,并强调需要临床意识.
主要方法:
- 一个没有糖尿病的年轻女性经历了EKA的病例介绍,同时接受了semaglutide治疗.
- 对与GLP-1受体激动剂相关的EKA病例报告现有文献的综述,特别是semaglutide和tirzepatide.
主要成果:
- 患者是一名非糖尿病女性,接受了塞马格卢提德治疗7个月,患上了EKA.
- 用含碳酸盐的乳糖输液治疗迅速解决了酸性脂肪酸症.
- 文献搜索显示,在非糖尿病患者中,Tirzepatide与EKA一起发生的一例病例,但之前没有与Semaglutide相关的病例.
结论:
- 优糖性酸性酸症是使用西马格卢提德的潜在风险,即使在没有糖尿病的个体中也是如此.
- 增加GLP-1抑制剂的使用可能会导致EKA病例的增加.
- 迅速识别和管理EKA对于有效的治疗和患者的结果至关重要.
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