孕产妇服用益生菌补充剂对母乳免疫成分的影响:来自SYMBA研究的见解
Nivedithaa Divakara1,2, Zac Dempsey2, Chitra Saraswati2
1Larsson-Rosenquist Foundation Centre for Immunology and Breastfeeding, Medical School, University of Western Australia, Perth, Western Australia, Australia.
概括
孕产妇服用益生菌补充剂改变了人乳 (HM) 中的特定免疫蛋白. 这表明,饮食干预可以改变母乳.
科学领域:
- 人母奶的成分 人母奶的成分
- 婴儿免疫学 婴儿免疫学
- 营养科学 营养科学
背景情况:
- 人母乳 (HM) 含有免疫调节蛋白,对婴儿免疫发育至关重要.
- 在HM中调节这些蛋白质的策略尚不清楚.
- 这项研究探讨了孕产妇服用益生菌补充剂对HM免疫调节蛋白水平的影响.
研究的目的:
- 为了调查母体的益生菌补充剂是否会改变母乳中特定免疫调节蛋白的水平.
- 了解饮食影响母乳免疫性能的潜在机制.
- 为孕妇和哺乳期妇女的饮食建议提供信息.
主要方法:
- 这是一项双盲随机对照试验 (SYMBA研究),涉及孕产妇服用益生菌 (短链银酸/长链果酸) 或安慰剂补充.
- 从产后2,4个月和6个月的母婴二中采集了HM样本.
- 测量了24种免疫调节蛋白的水平HM从前生物组的46名妇女和安慰剂组的54名妇女.
主要成果:
- 总的来说,免疫调节蛋白质的概况在各组之间是相似的.
- 在产后2个月,益生菌补充与TGF-β1和TSLP水平的降低有关,并在HM中增加sCD14.
- 在产后4个月,IgG1水平在益生菌组比安慰剂组更低.
结论:
- 孕产妇摄入益生菌可以选择性地改变母乳中特定的免疫调节蛋白.
- 这些发现突出了一个潜在的饮食策略来修改HM的免疫组成.
- 这可以通过通过母乳养来增强免疫支持来影响婴儿健康结果.
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