导致牛分娩的荷尔蒙特征和生物标志物†
Pedo L J Monteiro1,2, Milo C Wiltbank2, Waneska S Frizzarini2
1Department of Large Animal Clinical Sciences, University of Florida, 2015 SW 16th Ave., Gainesville, FL 32608, USA.
Biology of reproduction
|September 2, 2024
概括
雌激素和孕期特异性蛋白B等荷尔蒙变化在奶牛中信号即将出生的信号,从前14天开始. 这些生物标志物和不同的荷尔蒙特征有助于预测分娩时间和胎盘成熟.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 兽医生理学 兽医生理学
背景情况:
- 分娩是一个复杂的生理过程,涉及激素变化.
- 确定可靠的生物标志物来预测分娩对于畜牧管理至关重要.
研究的目的:
- 阐明奶牛分娩的生理机制.
- 为了确定出生开始的预测生物标志物.
- 为了比较不同孕期的奶牛之间的荷尔蒙特征.
主要方法:
- 每天抽取18头奶牛的血液样本,从预期分娩前28天到分娩后3天.
- 使用RIA,ELISA和色度测定方法量化孕激素,雌激素 (E2),,前列腺素F2α代谢物,皮质醇,妊娠特异性蛋白B和乳酸.
主要成果:
- 孕激素水平在两个阶段显著下降:从d-14到d-4以及从d-2到分娩.
- 前列腺素F2α代谢物度从d-2到分娩时急剧增加.
- 雌激素和妊娠特异性蛋白B显示,从分娩前13天左右开始,大约增加了8倍,而雌激素显示出更快的上升.
- 皮质醇和乳酸盐水平只有在分娩时才达到峰值.
- 在孕期较短和较长的母牛之间观察到雌激素和前列腺素F2α代谢物模式的明显差异.
结论:
- 雌激素和妊娠特异性蛋白B成为关键生物标志物,在分娩前14天可以检测到显著的变化.
- 荷尔蒙概况表明,妊娠期较短和较长的母牛之间胎盘成熟的差异,这表明早期预测的潜力.
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