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在被诊断为COVID-19的患者中,不成熟的血小板分数
Neha Parashar1, Rashmi J Gupta1, Divya Gupta2
1Department of Clinical Pathology, Lok Nayak Hospital, New Delhi, India.
Indian journal of pathology & microbiology
|September 2, 2024
概括
血小板数量较低的COVID-19患者表现出较高的不成熟血小板分数 (IPF),表明血小板破坏. 这表明COVID-19中的血小板缺血可能是由于周围血小板消耗.
科学领域:
- 血液学 血液学 血液学
- 病毒学 病毒学
- 关键护理医学 关键护理医学
背景情况:
- 由SARS-CoV-2引起的COVID-19与血栓栓塞栓事件和血栓细胞衰减有关.
- 血小板缺血可能是由于血小板破坏/消耗的增加或骨髓生产的减少造成的.
- 不成熟的血小板分数 (IPF) 作为外周血小板破坏和消耗的指标.
研究的目的:
- 在被诊断为COVID-19的患者中评估未成熟的血小板分数 (IPF).
主要方法:
- 来自68名入院于德里三级医院的COVID-19患者的实验室记录的回顾性分析.
- 分析了血小板参数,包括血小板计数,平均血小板体积 (MPV),IPF和血小板大细胞比率 (P-LCR).
- 使用SPSS版本25来确定统计意义,P<0.05被认为是显著的.
主要成果:
- 在40%的COVID-19患者中观察到轻度血小板缩.
- 较低的血小板计数与显著更高的IPF,MPV,PDW和P-LCR相关.
- 在IPF和血小板计数 (P<0.05) 之间发现了显著的反向关系.
- IPF与MPV和P-LCR (P <0.05) 显示出显著的正相关性.
结论:
- 在COVID-19患者中,血小板缺血很可能归因于外周血小板的破坏和消耗.
- 升高的IPF水平可能作为COVID-19相关的血小板消耗的生物标志物.
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