时间可变的有毒物质暴露的环境风险评估,并对子致命终点和移动时间窗口的毒动力学-毒动力学建模:Ceriodaphnia dubia的病例研究
Carlo Romoli1, Marie Trijau1, Erik B Muller1,2
1ibacon, Roßdorf, Germany.
Environmental toxicology and chemistry
|September 2, 2024
概括
使用动态能源预算 (DEB-TKTD) 模型的毒动力学-毒动力学 (TKTD) 建模,完善化学风险评估. 一个用Ceriodaphnia dubia和azoxystrobin的案例研究证明了它的应用,从实验室测试到环境预测.
科学领域:
- 环境毒理学环境毒理学
- 生态毒理学 生态毒理学
- 风险评估 风险评估
背景情况:
- 像TKTD这样的机制模型对于监管化学品风险评估至关重要.
- DEB-TKTD模型整合了个别的生物测试数据,以预测次致命效应.
- 应用DEB-TKTD模型的彻底案例研究有限.
研究的目的:
- 介绍DEB-TKTD模型应用的综合案例研究.
- 展示从实验室测试到环境风险评估的过程.
- 在Ceriodaphnia dubia上评估杀菌剂阿佐克西斯特罗宾.
主要方法:
- 根据经合组织TG 211进行的良好实验室实践 (GLP) 毒性研究.
- 使用定制实验室数据校准DEB-TKTD模型参数.
- 验证了DEBtox2019模型并将其应用于FOCUS暴露场景.
主要成果:
- 成功校准和验证了DEB-TKTD模型的阿佐克西斯特罗宾.
- 在可变时间的地表水暴露场景下预测的影响.
- 使用移动时间窗口方法进行环境风险评估.
结论:
- DEB-TKTD建模为化学风险评估提供了一个强大的框架.
- 这种方法减少了不确定性,并提高了风险评估的一致性.
- 这项研究提供了一个适用于监管科学的最先进的例子.
关键词:
亚基斯特罗宾 (AZOXYSTROBIN) 是一种在Ceriodaphnia dubia中,它们的长度很大.动态能源预算是一个动态能源预算.环境风险评估环境风险评估脉冲暴露暴露时间为1小时.毒性动力学毒性动力学建模更多相关视频
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