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Updated: Jun 14, 2025

LDL Cholesterol Uptake Assay Using Live Cell Imaging Analysis with Cell Health Monitoring
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LDL Cholesterol Uptake Assay Using Live Cell Imaging Analysis with Cell Health Monitoring

Published on: November 17, 2018

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在LDLR,APOB和PCSK9的罕见遗传变异与大动脉狭窄有关

Joel T Rämö1,2,3,4, Sean J Jurgens1,2,5,6, Shinwan Kany1,2,5,7,8

  • 1Cardiovascular Disease Initiative (J.T.R., S.J.J., S. Kany, X.W., S. Khurshid, P.T.E., J.P.P.), Cambridge, MA.

Circulation
|September 2, 2024
PubMed
概括

一生高的LDL-C由遗传变异显著增加大动脉狭窄的风险,而一生低的LDL-C则降低了风险. 早期的降脂疗法可以预防或减缓AS的发展.

关键词:
大动脉狭窄症胆固醇遗传学脂质脂肪蛋白,LDL磁共振成像接收器,LDL

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Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
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