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外源S1P通过S1P受体2诱导CTGF通过Src-RhoA-ROCK-YAP通路在肝星细胞中的表达

Suhyun Park1, Jonghwa Kim2, Sera Yang3

  • 1Department of Health Science and Technology, SAIHST, Sungkyunkwan University, 81 Irwon-Ro, Gangnam-Gu, Seoul, 06351, South Korea.

Molecular biology reports
|September 2, 2024
PubMed
概括

斯芬哥辛1-酸盐 (S1P) 通过S1P受体2 (S1PR2) 激活肝星细胞 (HSC),促进肝纤维化. 准S1PR2-Hippo-YAP通路为肝纤维化提供了一个潜在的治疗策略.

关键词:
细胞骨的重新安排肝脏纤维化 肝脏纤维化肝脏的星状细胞.在Hippo-YAP信号通路中.斯芬哥辛1-酸盐 (S1P) 是一种斯芬哥辛1-酸盐受体 (S1PR) 是一种

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