一个形态粘性弹性理论,用于增殖聚合物的增长
Prakhar Bandil1, Franck J Vernerey2
1Department of Mechanical Engineering, University of Colorado, Boulder, USA.
Biomechanics and modeling in mechanobiology
|September 2, 2024
概括
这项研究引入了一种新的多尺度模型,用于模拟3D组织中的生物生长. 它解释了细胞分裂,扩张和间隔,改进了像有机体这样的增殖聚合物的模型.
科学领域:
- 连续机械学的连续力学.
- 多尺度建模的多尺度建模
- 发育生物学是发展生物学.
背景情况:
- 现有的模型忽略了活跃生长动态中的细胞水平形态遗传行为.
- 细胞分裂和扩张的连续治疗存在挑战,用于生长建模.
- 目前的模型仅限于2D,不能扩展到3D多细胞系统.
研究的目的:
- 为3D生物生长提供一个通用的多尺度模型.
- 为了将细胞分裂,扩张和间隙结合到连续理论中.
- 为了使增殖聚合物中生长和消散机制的全面探索.
主要方法:
- 开发了一个通用的多尺度连续模型.
- 扩展模拟能力到三维多细胞系统.
- 集成的细胞分裂,扩张和合过程.
主要成果:
- 该模型在3D聚合物中解释了复杂的形态遗传运动.
- 能够详细研究生殖组织的生长动态.
- 为分析生长过程中的消散力学提供了一个框架.
结论:
- 拟议的模型解决了当前生物生长模拟的局限性.
- 它提供了一种全面的方法来建模3D多细胞生长.
- 促进了对有机体和球体发育的更深入的理解.
相关概念视频
Plastic Behavior
192
A material's elastic behavior is characterized by the disappearance of stress once the load is removed, allowing the material to return to its original state. However, when stress surpasses the yield point, yielding commences, marking the onset of plastic deformation or permanent set. This change from elastic to plastic behavior is influenced by the peak stress value and the duration before the load is removed. An intriguing observation occurs when a specimen is loaded, unloaded, and...
192
Relation between Poisson's ratio, Modulus of Elasticity and Modulus of Rigidity
253
Deformation occurs in axial and transverse directions when an axial load is applied to a slender bar. This deformation impacts the cubic element within the bar, transforming it into either a rectangular parallelepiped or a rhombus, contingent on its orientation. This transformation process induces shearing strain. Axial loading elicits both shearing and normal strains. Applying an axial load instigates equal normal and shearing stresses on elements oriented at a 45° angle to the load axis.
253
Generalized Hooke's Law
868
The generalized Hooke's Law is a broadened version of Hooke's Law, which extends to all types of stress and in every direction. Consider an isotropic material shaped into a cube subjected to multiaxial loading. In this scenario, normal stresses are exerted along the three coordinate axes. As a result of these stresses, the cubic shape deforms into a rectangular parallelepiped. Despite this deformation, the new shape maintains equal sides, and there is a normal strain in the direction of the...
868
Members Made of Elastoplastic Material
94
The behavior of elastoplastic materials under bending stresses, particularly in structural members with rectangular cross-sections, is crucial for predicting material responses and understanding failure modes. Initially, when a bending moment is applied, the stress distribution across the section follows Hooke's Law and is linear and elastic. This distribution means the stress increases from the neutral axis to the maximum at the outer fibers, up to the elastic limit.
As the bending moment...
As the bending moment...
94
Hooke's Law
357
Hooke's law, a pivotal principle in material science, establishes that the strain a material undergoes is directly proportional to the applied stress, defined by a factor called the modulus of elasticity or Young's modulus.
357
Shearing Strain
236
The shearing strain represents a cubic element's angular change when subjected to shearing stress. This type of stress can transform a cube into an oblique parallelepiped without influencing normal strains. The cubic element experiences a significant transformation when exposed solely to shearing stress. Its shape alters from a perfect cube into a rhomboid, clearly demonstrating the effect of shearing strain. The degree of this strain is considered positive if it reduces the angle between...
236


