在真菌角膜炎中体外敏感性和临床结果之间的关联
Louisa Lu1, N Venkatesh Prajna2, Prajna Lalitha2
1Department of Ophthalmology, Byers Eye Institute, Stanford University, 2542 Watson Ct, Palo Alto, Stanford, CA, 94303, USA.
Journal of ophthalmic inflammation and infection
|September 2, 2024
概括
在真菌角膜炎中,较低的对沃里康纳的敏感性与Fusarium感染的较差结果相关,包括更高的角膜移植需求. 纳塔米辛敏感性没有显示出结果相关性.
科学领域:
- 眼科医生 眼科 眼科
- 菌类学 菌类学是指菌类学.
- 传染性疾病 传染性疾病
背景情况:
- 真菌角膜炎是视力障碍的重要原因之一.
- 抗真菌最小抑制度 (MIC) 对于指导治疗至关重要.
- 了解抗真菌敏感性和临床结果之间的联系对于有效的管理至关重要.
研究的目的:
- 评估由MIC测量的抗真菌药物敏感性与真菌角膜炎患者的临床结果之间的关联.
- 调查纳塔米辛和沃里康纳MIC与视力敏度,角膜痕,穿孔和手术需要之间的关系.
主要方法:
- 对性治疗试验II (MUTT II) 进行了二次分析.
- 对纳他素和沃里康纳的抗真菌敏感性测试 (MIC) 在阳性真菌培养物上进行.
- 评估了临床结果,包括视力敏度,透物大小和透性角质形成手术的需要.
主要成果:
- 在抗真菌MIC和真菌角膜炎的临床结果之间没有发现整体关联.
- 在富沙阳性病例中,较高的伏利可纳MIC与视力敏度降低相关,治疗性透角膜整形的需求增加,以及更长的再上皮化时间.
- 纳塔米辛MIC和临床结果之间没有显著的相关性,也没有观察到voriconazoleMIC和Aspergillus阳性病例的结果之间有显著的相关性.
结论:
- 对伏利康纳的敏感性降低与在Fusarium阳性真菌角膜炎中需要治疗性穿透性角膜整形的可能性更高有关.
- 在本研究中,抗真菌敏感性与纳塔米辛的抗真菌敏感性没有与任何测量的临床结果显示相关性.
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