在精神分裂症患者的任务诱导大脑中发现了受损的认知网络
Seungho Kim1, Sang Won Lee2,3, Hansol Lee1
1Department of Medical & Biological Engineering, Kyungpook National University, Daegu, Korea.
Brain imaging and behavior
|September 2, 2024
概括
精神分裂症患者在苛刻的任务中脑 (BEN) 减少,特别是在额头和海马区域. 这种减少与认知缺陷和症状相关,表明BEN是精神分裂症潜在的神经成像标志物.
科学领域:
- 神经成像是一种神经成像.
- 认知神经科学 认知神经科学
- 精神病学是一个精神病学.
背景情况:
- 大脑 (BEN) 量化了大脑活动中的信息,为大脑功能提供了洞察力.
- 休息状态fMRI研究显示,在精神分裂症 (SCZ) 中发生了改变的BEN.
- 在SCZ中依赖任务的BEN仍未得到充分研究,特别是在认知缺陷方面.
研究的目的:
- 在精神分裂症 (SCZ) 认知任务期间调查任务引起的大脑 (BEN) 的动态变化.
- 探索任务BEN,工作记忆 (WM) 能力和SCZ中的临床症状之间的关联.
- 确定任务BEN是否可以作为SCZ认知缺陷的神经成像标记.
主要方法:
- 在N-back任务中分析了15名SCZ患者和15名健康对照 (HC) 的fMRI数据.
- 计算了任务BEN,并检查了与双背任务性能,临床症状和神经心理评分的相关性.
- 在不同脑区的SCZ和HC组之间比较任务BEN值.
主要成果:
- 与HC相比,SCZ患者在小脑,海马体,副海马体,丘脑,中额头 (MFG) 和上额头 (SFG) 中显著减少了任务BEN.
- 在HC中,任务BEN与MFG和SFG中的2回准确度有正相关;在SCZ中,这些相关性不存在.
- 在SCZ中,任务BEN与积极和消极症状负面相关,特别是在副海马圈.
结论:
- 在高认知需求任务期间,前额头和海马区域的减少任务BEN与SCZ的认知缺陷有关.
- 任务 BEN 变化可能代表精神分裂症相关认知障碍的神经成像生物标志物.
- 这项研究强调了任务唤起的BEN在理解SCZ认知功能障碍方面的实用性.
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