患有心力衰竭的患者的日常体育活动和预后影响:加速仪研究
Andreas Bugge Tinggaard1,2, Lotte Sørensen3, Kristian Vissing4
1Department of Cardiology, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200, Aarhus N, Denmark. andreas.bugge@midt.rm.dk.
概括
与对照组相比,心力衰竭 (HF) 患者的体力活动显著降低. 加速度计数据与身体能力相关,但与HF患者的LVEF或NT-proBNP无关.
科学领域:
- 心脏病学 心脏病学
- 运动生理学 运动生理学
- 生物医学工程 生物医学工程
背景情况:
- 通过加速度计测量体力活动 (PA) 是潜在的新型心力衰竭 (HF) 试验终点.
- 缺少标准化的方法和与HF加速计的已建立标记器的关联.
- 这项研究调查了PA测量,加速度计的重复性,以及与HF预后标志物的相关性.
研究的目的:
- 检查身体活动 (PA) 测量和加速度计在心力衰竭 (HF) 患者和对照组中的重复性.
- 研究加速计衍生PA与已确定的预后性HF标志物,身体组成和生活质量 (QoL) 之间的相关性.
主要方法:
- 105名高压患者 (LVEF ≤ 40%) 和46名对照人进行了加速度计.
- 参与者还完成了双X射线吸收计,心肺运动测试,6分钟步行测试 (6MWT),心声扫描,NT-proBNP测量和QoL问卷.
主要成果:
- 与对照组 (27.2毫克) 相比,HF患者的平均加速显著减少 (16.1毫克).
- HF患者在中度至强度的PA中花费的时间显著减少 (12分钟/天) 与对照组 (56分钟/天) 相比.
- 在HF患者中,平均加速与6MWT和峰值VO2有适度的相关性,但与NT-proBNP,LVEF或QoL没有相关性.
结论:
- 与健康人相比,HF患者的日常体力活动严重减少.
- 加速度计测量显示,HF患者的身体能力标志物与中度相关性.
- 在这个HF队列中,加速度计数据与LVEF或NT-proBNP没有相关性.
相关概念视频
01:17Exercise and Cardiac Output
946
Regular physical activity is essential for maintaining cardiovascular health, with aerobic exercises being particularly effective. According to the American Heart Association, 150 minutes of moderate to intense aerobic exercise per week is recommended for a healthy heart. Aerobic activities may include brisk walking, running, bicycling, cross-country skiing, and swimming, ideally performed three to five times per week.
Sustained exercise increases the muscles' oxygen demand, which can be...
Sustained exercise increases the muscles' oxygen demand, which can be...
946
01:20Exercise and Cardiovascular Response
750
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
750
01:17Pathophysiology of Heart Failure
1.5K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
1.5K
01:30Pulse rhythm
775
Pulse rhythm refers to the pattern of pulsations within specific intervals, offering valuable insights into the regularity or irregularity of the heart's beats as observed through the pattern of pulsation within specific intervals. A regular pulse exhibits a consistent heart rate with uniform waveforms and pulsation force, variations of which can be classified as normal, weak, or bounding.
Conversely, an irregular pulse pattern is termed dysrhythmia, stemming from disruptions in cardiac...
Conversely, an irregular pulse pattern is termed dysrhythmia, stemming from disruptions in cardiac...
775
01:22Heart Failure Drugs: β-Blockers
322
β-adrenergic antagonists, commonly known as β-blockers, block the effects of sympathetic neurotransmitters such as noradrenaline (NA) and adrenaline (ADR). They have several beneficial effects in heart failure treatment. They reduce heart rate, the force of contraction, and cardiac muscle relaxation. They also slow the atrial-ventricular conduction rate and raise the threshold for arrhythmias. The concentration of β-blockers determines their effects on bronchodilation,...
322
01:26Heart Failure Drugs: Inotropic Agents
545
Positive inotropic agents are commonly used as the first line of treatment for heart failure. One such agent is digoxin, derived from the genus Digitalis, which has been known for centuries but effectively utilized since 1785. However, these cardiac glycosides can have potentially toxic effects due to their mechanism of action, which involves inhibiting Na+/K+-ATPase and increasing contractility. Digoxin is absorbed orally and distributed in various tissues, including the CNS. It has a long...
545