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相关概念视频

Prismatic Beams: Problem Solving01:15

Prismatic Beams: Problem Solving

108
In the design of a supported timber beam subjected to a distributed load, both the beam's physical dimensions and the timber's characteristics, such as its grade and species, are critical. These factors determine the allowable stress values, which are crucial for calculating the necessary beam depth to ensure structural integrity and safety.
The design begins with analyzing the beam as a free body to identify moments and force balances, thereby determining support reactions. Next, the...
108
Design of Prismatic Beams for Bending01:23

Design of Prismatic Beams for Bending

220
The design of prismatic beams, structural elements with a uniform cross-section, focuses on ensuring safety and structural integrity under load. The design process begins by determining the allowable stress, either from material properties tables, or by dividing the material's ultimate strength by a safety factor. This safety factor is essential for accommodating uncertainties, and varies depending on the material—timber, steel, or concrete—with each having unique strength and...
220
Transmission Shafts: Problem Solving01:09

Transmission Shafts: Problem Solving

218
Designing a solid shaft that transmits power from a motor to a machine tool involves a series of calculations to ensure the shaft can withstand the stresses applied by bending moments and torques. First, calculate the torque exerted on the gear, considering the power transmitted by the shaft and its rotational speed. Following this, compute the tangential forces acting on the gears, which directly relate to the torque and the gear radius.
Next, use bending moment diagrams for the shaft to...
218
Properties of the z-Transform I01:17

Properties of the z-Transform I

173
The z-transform is a fundamental tool in digital signal processing, enabling the analysis of discrete-time systems through its various properties. It is an invaluable tool for analyzing discrete-time systems, offering a range of properties that simplify complex signal manipulations. One fundamental property is linearity. For any two discrete-time signals, the z-transform of their linear combination equals the same linear combination of their individual z-transforms. This property is essential...
173
Design of Transmission Shafts01:16

Design of Transmission Shafts

287
The design of a transmission shaft is governed by two primary specifications: the power it transmits and its rotational speed. These parameters guide the selection of the shaft's material and cross-sectional dimensions, ensuring that the material's maximum shearing stress remains within the elastic limit while transmitting the desired power at the given speed. The system's power is intrinsically linked to the applied torque. The torque applied to the shaft can be calculated by...
287

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相关实验视频

Updated: Jun 14, 2025

Design and Optimization Strategies of a High-Performance Vented Box
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Design and Optimization Strategies of a High-Performance Vented Box

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提示加速BOIN设计的方法

Masahiro Kojima1, Wu Wende2, Henry Zhao2

  • 1Biometrics Department, Research Division, Kyowa Kirin Co., Ltd. Otemachi Financial City Grand Cube, 1-9-2 Otemachi, Chiyoda-ku, Tokyo, 100-004, Japan. kojima.masahiro@ism.ac.jp.

Therapeutic innovation & regulatory science
|September 2, 2024
PubMed
概括

我们开发了一个加速的贝叶斯最佳间隔 (BOIN) 设计,以加快早期临床试验. 这种新方法与传统的3+3设计的速度相匹配,减少了研究持续时间和患者数量.

科学领域:

  • 临床试验 临床试验
  • 生物统计学 生物统计学
  • 药物开发 药物开发

背景情况:

  • 标准的3+3设计被广泛用于剂量升级,但可能是漫长的.
  • BOIN设计提供了统计上的优势,但由于研究持续时间较长和样本规模较大,它面临着采用障碍.

研究的目的:

  • 为I期临床试验引入加速的BOIN设计.
  • 为了使BOIN设计能够达到与3+3设计相提并论的速度.
  • 为了证明BOIN设计在一个主要使用3+3设计的公司中的适用性.

主要方法:

  • 通过整合一个高效的停止标准,开发了一个加速的BOIN设计.
  • 拟议的方法涉及终止剂量升级,如果6名患者在当前剂量可评估和决定是留下来.
  • 对于较低剂量,如果非临床研究没有显示出安全问题,则较小的队列规模被认为是可行的.

主要成果:

  • 与标准BOIN设计相比,加速BOIN设计在正确的最大耐受剂量 (MTD) 选择中显示出 -2.43%的平均差异.
  • 加快的BOIN设计使平均研究时间减少了14.8个月.
  • 与标准BOIN设计相比,平均样本大小减少了9.22名患者.
关键词:
3 + 3 设计设计加速的BOIN设计设计.

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相关实验视频

Last Updated: Jun 14, 2025

Design and Optimization Strategies of a High-Performance Vented Box
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Design and Optimization Strategies of a High-Performance Vented Box

Published on: June 9, 2023

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A Modeling and Simulation Method for Preliminary Design of an Electro-Variable Displacement Pump
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A Modeling and Simulation Method for Preliminary Design of an Electro-Variable Displacement Pump

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A Soft Tooling Process Chain for Injection Molding of a 3D Component with Micro Pillars

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结论:

  • 加速BOIN设计为剂量升级提供了3+3设计的可行替代方案.
  • 这种加速方法保持了统计学严谨性,同时提高了试验效率.
  • 这些发现支持在早期瘤学试验中更广泛地采用BOIN设计.