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常见便免疫化学测试的比较性能:一个横截面研究

Barcey T Levy¹, Yinghui Xu², Jeanette M Daly²

¹University of Iowa Carver College of Medicine; University of Iowa College of Public Health; and Holden Comprehensive Cancer Center, University of Iowa, Iowa City, Iowa (B.T.L.).

Annals of internal medicine

|September 2, 2024

概括

用于结直肠癌查的便免疫化学测试 (FIT) 在性能上有很大差异. 由于检测晚期结直肠瘤的灵敏度和特异性的差异,这些测试不应被认为是可互换的.

科学领域:

胃肠病学胃肠病学
在瘤学瘤学.
诊断医学诊断医学

背景情况:

便免疫化学测试 (FITs) 被广泛用于结直肠癌 (CRC) 查.
现有的数据有限,以指导选择特定的FIT品牌进行最佳选.

研究的目的:

为了比较五种常用的FIT用于结直肠癌查的性能特征.
用结肠镜作为参考标准来评估不同FIT的敏感性和特异性.

主要方法:

一项涉及3761名年龄在50-85岁之间的参与者进行的横截面研究,他们正在接受结肠镜检查.
参与者完成了五种不同的FIT;绩效与高级结肠直肠瘤 (ACN) 的结肠镜检查结果进行了评估.

主要成果:

测试阳性率在FIT中变化四倍,从3.9%到16.4%.
对ACN的敏感度在10.1%至36.7%之间,特异性在85.5%至96.6%之间.
大多数FIT品牌之间观察到敏感度和特异性的显著差异.

结论:

便免疫化学测试 (FIT) 在检测晚期结直肠瘤方面表现不同.
不同的FIT品牌是不可互换的,测试选择可能会影响选的有效性.

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