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在美国成年人中,石史与心血管事件风险之间的关联
Samir Bhattacharyya1, Larry E Miller2, Silvia Proietti3
1Health Economics and Market Access, Boston Scientific, Marlborough, MA.
Urology
|September 2, 2024
概括
患有结石的病史与较高的动脉样硬化心血管疾病 (CVD) 事件的10年风险有关,特别是在男性中. 这表明,增加心血管查可能对有结石病史的个人有益.
科学领域:
- 心脏病学 心脏病学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 流行病学 流行病学
背景情况:
- 动脉样性心血管疾病 (CVD) 仍然是全球主要的死亡原因.
- 结石是一种常见的疾病,具有潜在的全身影响.
- 在一般人群中,石史与未来心血管疾病风险之间的关系尚未完全阐明.
研究的目的:
- 调查结石病史与动脉样硬化心血管疾病事件预测的10年风险之间的关联.
- 为了在美国成年人没有先前存在的心血管疾病的全国代表性样本中检查这一关联.
- 探索这种关联中潜在的基于性别的差异.
主要方法:
- 2017-2020年国家健康和营养检查调查 (NHANES) 的横截面分析.
- 包括3842名美国成年人,年龄在40-79岁之间,没有患有心血管疾病.
- 通过自我报告评估结石病史和预测10年动脉样硬化心血管疾病风险,使用ACC/AHA聚合队列方程.
主要成果:
- 结石的加权患病率为12.2%.
- 患有结石病史的个体具有更高的边界或更高 (≥5%) 预测的10年动脉样硬化心血管疾病风险 (OR=1.57;95% CI:1.02-2.43).
- 观察到性别的显著相互作用,结石在男性中具有过度风险,但在女性中没有 (P=0.002).
结论:
- 石史是增加10年动脉样硬化心血管疾病风险的独立预测因素.
- 这种关联在男性中比女性更明显.
- 在有结石病史的个人,特别是男性中,可能需要考虑加强心血管疾病查.
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