黄类药物摄入量,慢性阻塞性肺病,成人喘和肺功能:英国生物银行的队列研究
Nicola P Bondonno1, Benjamin H Parmenter2, Alysha S Thompson3
1Institute for Nutrition Research, School of Medical and Health Sciences, Edith Cowan University, Perth, Australia; The Danish Cancer Society Research Centre, Copenhagen, Denmark; Institute for Global Food Security, Queen's University Belfast, Northern Ireland.
The American journal of clinical nutrition
|September 2, 2024
概括
更高的黄类药物摄入量与慢性阻塞性肺病 (COPD) 风险降低和肺功能改善有关,特别是在吸烟者中. 促进茶,果和果等富含黄胺的食物可能有利于呼吸系统健康.
科学领域:
- 营养流行病学 营养流行病学
- 呼吸系统医学 呼吸系统医学
- 公共卫生 公共卫生
背景情况:
- 黄素具有抗氧化,抗过敏,抗炎和免疫调节的特性.
- 这些特性表明,黄素在预防慢性阻塞性肺病 (COPD) 和喘方面可能发挥作用.
研究的目的:
- 调查黄类消费与COPD和喘发病率之间的关联.
- 检查黄类药物摄入量与肺功能指标之间的关系.
主要方法:
- 一项包括119,466名英国生物库参与者 (平均年龄60岁) 的队列研究.
- 用24小时的饮食回忆来评估黄素摄入量,计算总黄素,子类,富含黄素的食物和黄素饮食评分.
- 使用考克斯和线性回归模型分析了与发生的COPD/喘和肺功能 (FEV1,FEV1/FVC) 的关联,并通过炎症 (INFLA评分) 和吸烟状况进行了调解.
主要成果:
- 适度至高摄入各种黄类子类和较高的黄饮食分数与高达18%的发生性COPD风险降低有关,但喘并非如此.
- 大多数黄类子类的较高摄入量和黄饮食得分与更好的基线百分比预测的1秒强迫呼气量 (FEV1) 相相关.
- 当前或前吸烟者中关联性更强,而黄类摄入量与INFLA得分相反,为特定黄类的COPD风险降低提供11% - 14%的介导作用.
结论:
- 中等到高的黄类药物消费与降低COPD风险和改善肺功能有关,特别是在有吸烟史的人群中.
- 鼓励食用富含黄胺的食物,如茶,果和果,可以改善呼吸系统健康,降低易感人群的COPD风险.
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