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混合电荷高分支聚合物纳米粒子具有选择性抗菌作用,用于对抗抗菌素耐药性

Yunyun Xue¹, Chuyao Wang², Yu Zhao²

¹Key Laboratory of Macromolecular Synthesis and Functionalization (Ministry of Education), Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China; Center of Healthcare Materials, Shaoxing Institute, Zhejiang University, Shaoxing 312000, China.

Acta biomaterialia

|September 2, 2024

概括

新的生物相容聚合物纳米粒子通过选择性向细菌来对抗抗菌素耐药性 (AMR). 这些纳米粒子为抗药性感染和生物膜形成的日益增长的威胁提供了有希望的解决方案.

科学领域:

生物材料科学生物材料科学
纳米技术纳米技术
传染性疾病传染性疾病

背景情况:

抗菌素耐药性 (AMR) 是一个关键的全球健康威胁.
现有的抗微生物药物往往缺乏选择性,伤害细菌和宿主细胞.
需要新的策略来对抗多药耐药细菌.

研究的目的:

设计和合成生物相容的混合电荷高分支聚合物纳米粒子 (MCHPNs).
评估MCHPNs对多药耐药细菌的抗菌活性和选择性.
探索MCHPNs作为涂料的潜力,以防止生物膜形成和感染.

主要方法:

合成和表征七个MCHPNs与不同的阴离子,阴离子和基群比率.
在体外和体内对抗菌疗效和哺乳动物细胞毒性的评估.
评估MCHPN涂层的生物膜抑制和免疫调节作用.

主要成果:

MCHPN7,具有27:59:14的阴离子:阴离子:基基的比率,证明了最佳的性能.
由于膜电位差异和水友性 (Kow = 0.04),MCHPN7对细菌细胞比哺乳动物细胞具有很高的选择性 (> 564).
MCHPN7有效地根除了抗生素耐药细菌,延迟了耐药性的出现,抑制了生物膜的形成,并减少了与感染相关的免疫反应.

结论:

生物相容的MCHPNs,特别是MCHPN7,代表了对抗AMR的一类有前途的药物.
选择性杀菌机制为传统抗菌剂提供了更安全的替代方案.
MCHPNs在伤口愈合,医疗器械涂层和感染控制等领域具有很大的应用潜力.

关键词:

抗微生物耐药性抗微生物耐药性生物相容性生物相容性超分支的聚合物纳米粒子.混合电荷 - 混合电荷有选择性的抗菌作用.

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