测试基于PANSS评级的电机评分:全面电机评估的代理
Niluja Nadesalingam1, Alexandra Kyrou1, Victoria Chapellier1
1Translational Research Center, University Hospital of Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland.
Schizophrenia bulletin
|September 2, 2024
概括
阳性和阴性综合征尺度运动分数 (PANSSmot) 有效地作为精神分裂症中低动力运动异常的代理. 这一发现有助于分析大量临床试验数据集,寻找潜在的治疗方法.
科学领域:
- 精神病学是一个精神病学.
- 神经科学是一个神经科学.
- 临床心理学 临床心理学
背景情况:
- 异常的精神运动行为是精神分裂症的关键症状,但使用专家尺度进行评估是困难的.
- 阳性和阴性综合征尺度 (PANSS) 包括与低动力运动行为相关的三个项目.
研究的目的:
- 评估特定PANSS项目的总分 (态度和姿势[G5],运动迟缓[G7],意愿障碍[G13]),称为PANSS运动分数 (PANSSmot),是否可以作为运动异常的代理.
- 评估PANSSmot与专家运动评分尺度的相关性及其区分患者群体的能力.
主要方法:
- 从两项临床试验 (n=196) 结合了基线数据,以与五个运动评级尺度相关联PANSSmot.
- 研究了每个PANSS运动项目的切线≥3 (PANSSmot总数≥9),以区分患者.
- 在独立试验 (n=102) 中重复发现,并通过体力活动测量评估纵向稳定性和有效性.
主要成果:
- PANSSmot与所有测试的电机尺度显示出显著的相关性 (斯皮尔曼-罗罗范围为0.19-0.52,P≤0.007).
- 建立的切线成功地将患者分为大多数尺度上的高和低运动得分组,但不包括异常非自愿运动尺度.
结论:
- PANSSmot评分是精神分裂症中低动力运动异常的潜在代理指标.
- 这种代理测量可能有助于分析大型数据集,以确定对精神病中低动力运动异常的干预措施.
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