在尘埃,头发和尿液中发现的德+:暴露,分泌和水平变化
Erde Wang1, Yan Zhang1, Tianwei Li1
1College of Life and Environmental Sciences, Minzu University of China, Beijing, 100081, China.
Environmental research
|September 2, 2024
概括
头发和尿液中的德克加 (DP) 含量在家中比在学校更高. 抗DP更多地与梅加林结合,导致syn-DP分泌,息地变化对正常体重学生的影响更大.
科学领域:
- 环境化学环境化学
- 毒理学 毒理学 毒理学
- 人类暴露科学科学 人类暴露科学
背景情况:
- 德加 (DP) 是一种在各种环境介质和人类中发现的持久性有机污染物.
- 了解DP在生物中的行为对于评估人类暴露和健康风险至关重要.
- 头发,尿液和尘埃分析为人类DP暴露和排泄模式的短期空间变化提供了洞察力.
研究的目的:
- 测量和分析学生的头发,尿液和室内灰尘中的Dechlorane Plus (DP) 度.
- 调查息地变化 (学校与家庭) 对DP水平的影响.
- 探索DP异构体,美加林结合和分泌模式之间的关系,考虑BMI和暴露史.
主要方法:
- 分析了32名北京大学生的头发,尿液和室内灰尘样本中的DP度.
- 在学校和家庭阶段的DP水平的比较.
- 分子对接模拟以评估DP异构体和梅加林蛋白之间的结合亲和力.
- 基于有机暴露实验参与和身体质量指数 (BMI) 的学生分类.
主要成果:
- 与学校阶段相比,在家庭阶段的头发,尿液和灰尘中DP度显著更高.
- 观察到头发中的syn-DP的选择性丰富和尿液中的syn-DP的选择性分泌.
- 分子对接表明抗DP和美加林之间的结合能更高,这表明抗DP的优先再吸收和随后的syn-DP分泌.
- 暴露组的DP水平高于未暴露组的DP水平.
- 与超重学生相比,生境变化对正常体重学生的DP积累和排泄产生了更大的影响.
结论:
- 息地转移在人类短期暴露和德克连 (DP) 的排泄动态中发挥着重要作用.
- DP异构体与美加林的差异性结合会影响它们在人体中的分布和分泌途径.
- 体重指数 (BMI) 和脂肪百分比可能会调节息地变化对DP积累的影响,正常体重的个体更容易受到环境变化的影响.
更多相关视频
10:10Assessment of the Acute Inhalation Toxicity of Airborne Particles by Exposing Cultivated Human Lung Cells at the Air-Liquid Interface
Published on: February 23, 2020
7.0K
09:29An Air-liquid Interface Bronchial Epithelial Model for Realistic, Repeated Inhalation Exposure to Airborne Particles for Toxicity Testing
Published on: May 13, 2020
11.4K
相关概念视频
Drug Excretion: Miscellaneous Routes
52
Drug excretion involves various organs, including the liver, intestines, skin, and eyes. In the case of drugs or toxins, they can be actively secreted into bile by transporters in the hepatocyte's canalicular membrane. These substances enter the GI tract during digestion and may be reabsorbed into the body from the intestine. This process, known as enterohepatic recycling, can significantly prolong the presence and effects of a substance in the body. To interrupt this cycle, specific...
52
Drug Excretion: Pulmonary and Glandular Routes
91
Gaseous substances like general anesthetics are absorbed and excreted through the lungs via simple diffusion. This process depends on factors such as pulmonary blood flow, respiration rate, and the substance's solubility. Gaseous anesthetics like nitrous oxide with low blood solubility are excreted rapidly, while compounds like alcohol, with high blood and tissue solubility, are excreted slowly.
Drugs can also be excreted in breast milk, which is crucial for breastfeeding infants. The...
Drugs can also be excreted in breast milk, which is crucial for breastfeeding infants. The...
91
Types of Toxins
1.7K
Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
1.7K
Drug Elimination: Overview
1.5K
Drug elimination involves many complex processes and does not necessarily differentiate between distribution and elimination. It is divided into two primary components: excretion and biotransformation.
Excretion refers to removing a drug from the body, either in its unchanged form or as its metabolites. Nonvolatile and polar drugs are primarily excreted through the kidneys, with other pathways including bile, sweat, saliva, and milk. Volatile drugs such as anesthetic gases are excreted via the...
Excretion refers to removing a drug from the body, either in its unchanged form or as its metabolites. Nonvolatile and polar drugs are primarily excreted through the kidneys, with other pathways including bile, sweat, saliva, and milk. Volatile drugs such as anesthetic gases are excreted via the...
1.5K
Enhanced Elimination of Poison
489
Poison can be effectively removed from the gastrointestinal (GI) tract through various decontamination procedures.
Antidotes serve a crucial role in counteracting the effects of poison by inhibiting enzymes responsible for producing harmful drug metabolites. In some cases, these toxic metabolites can be neutralized by endogenous cosubstrates, which are maintained at specific concentrations to prevent interaction with cellular macromolecules and subsequent cell death.
Renal excretion is the...
Antidotes serve a crucial role in counteracting the effects of poison by inhibiting enzymes responsible for producing harmful drug metabolites. In some cases, these toxic metabolites can be neutralized by endogenous cosubstrates, which are maintained at specific concentrations to prevent interaction with cellular macromolecules and subsequent cell death.
Renal excretion is the...
489
Drug Concentrations: Measurements
347
Drug concentration is the quantity of a drug present in a biological sample. Measuring drug amounts in biological samples allows the clinician to understand how a drug is absorbed, distributed, metabolized, and excreted. Samples can be obtained through invasive or non-invasive methods. Invasive techniques involve surgical or parenteral interventions to gather blood, cerebrospinal fluid, or tissue biopsy. Conversely, non-invasive approaches provide samples like urine, feces, and saliva.
Plasma...
Plasma...
347
