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纳米粒子可变性对多尺度生物运输的影响

Hytham H Gadalla1, Zhongyue Yuan2, Ziang Chen2

  • 1Department of Industrial and Molecular Pharmaceutics, Purdue University, 575 Stadium Mall Drive, West Lafayette, IN 47907, USA; Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt.

Advanced drug delivery reviews
|September 2, 2024
PubMed
概括

纳米粒子 (NP) 变形性对于药物输送至关重要,影响循环,生物分布和细胞相互作用. 本综述强调了最近关于NP可变形性的研究结果.

关键词:
原子力显微镜的原子力显微镜.生物运输 生物运输 生物运输可以变形的可变形性.药物输送是药物输送的过程.纳米颗粒是如何形成的

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Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
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