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Updated: Jun 14, 2025

In Vitro Differentiation of Human CD4+FOXP3+ Induced Regulatory T Cells (iTregs) from Naïve CD4+ T Cells Using a TGF-β-containing Protocol
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In Vitro Differentiation of Human CD4+FOXP3+ Induced Regulatory T Cells (iTregs) from Naïve CD4+ T Cells Using a TGF-β-containing Protocol

Published on: December 30, 2016

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发现一种针对蛋白解的嵌合体 (PROTAC) 作为FOXP3的有力调节剂

Bowen Yang1, Yanhong Cen2, Fangfang Li3

  • 1Tianjin University of Science and Technology, Tianjin 300457, China; Guangdong Key Laboratory of Nanomedicine, CAS-HK Joint Lab of Biomaterials, CAS Key Laboratory of Biomedical Imaging Science and System, Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology (SIAT), Chinese Academy of Sciences (CAS), Shenzhen 518055, China.

Bioorganic & medicinal chemistry letters
|September 2, 2024
PubMed
概括

这项研究引入了P60-L3-VHL,一种新的PROTAC分子,可降解叉头盒P3 (Foxp3) 蛋白. 这种降解抑制了调控性T细胞分化,为增强癌症免疫治疗提供了潜在的潜力.

关键词:
福克斯p3p3 在线观看这就是PROTAC.这是Tregs.

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