揭开子宫内膜异位症与发展静脉血栓栓塞的风险之间的因果关系:一个聚合分析
Pauline De Corte1,2, Igor Milhoranca1, Sylvia Mechsner3
1Berlin Center for Epidemiology and Health Research, Berlin, Germany.
Thrombosis and haemostasis
|September 2, 2024
概括
使用口服避孕药的子宫内膜异位症妇女患有静脉血栓塞栓症 (VTE) 的风险更高. 这项研究发现,子宫内膜异位症在口服避孕药使用者中增加了79%的静脉瘤风险.
科学领域:
- 生殖健康 生殖健康
- 心血管健康 心血管健康
- 药物监督 药物监督 药物监督
背景情况:
- 子宫内膜异位症是一种慢性炎症性疾病,影响生殖年龄的女性.
- 静脉血栓栓塞 (VTE) 是与口服避孕药 (OC) 使用相关的已知风险.
- 在OC使用者中,子宫内膜异位症和VTE风险之间的相互作用需要进一步调查.
研究的目的:
- 为了研究子宫内膜异位症和使用口服避孕药的女性中静脉突发症风险之间的关联.
- 量化OC使用者具有和没有子宫内膜异位症的VTE风险.
主要方法:
- 这是对三项以患者为中心的国际队列研究 (INAS-VIPOS,INAS-SCORE,INAS-FOCUS) 的统一数据的综合分析.
- 包括11个欧洲国家,美国和加拿大的新处方OC的患者,包括有或没有子宫内膜异位症的患者,并且没有先前的VTE病史.
- 使用稳定治疗权重的逆概率 (IPTW) 来计算VTE的调整危险比率 (HRs) 的时间到事件分析.
主要成果:
- 这项研究包括22,072名患有子宫内膜异位症的妇女和91,056名没有子宫内膜异位症的妇女.
- 患有子宫内膜异位症的女性的静脉瘤发病率 (IR) 为每1万女性年5.2,而没有子宫内膜异位症的女性的发病率为每1万女性年4.1.
- 经过对相关共变量进行调整后,子宫内膜异位症与OC使用者的VTE危险比率增加了79% (HR: 1.79; 95% CI: 1.24-2.57).
结论:
- 子宫内膜异位症被确定为女性使用口服避孕药的VTE风险的一个重要因素.
- 医疗保健提供者在评估OC使用者的VTE风险时应考虑子宫内膜异位症状态.
- 需要进一步的研究来阐明将子宫内膜异位症与VTE联系在一起的潜在机制.
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