冈比亚农村儿童的呼吸率:基于社区的队列研究
Polycarp Mogeni1,2, Sharon Amima3, Jennifer Gunther4
1Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK. pkambona11@gmail.com.
Scientific reports
|September 2, 2024
概括
这项研究为热带地区的1至13岁儿童建立了新的呼吸速率 (RR) 参考图表. 它还建议在5岁以上的儿童中提高RR截止值>26次/分钟,改善这个年龄组的诊断.
科学领域:
- 儿科 儿科 儿科
- 热带医学 热带医学
- 公共卫生 公共卫生
背景情况:
- 热带地区的幼儿的正常呼吸速率 (RR) 已被记录在案,但对较大的儿童的数据很少.
- 准确的RR评估对于诊断儿童的呼吸系统疾病至关重要,特别是在资源有限的环境中.
研究的目的:
- 建立6个月至14岁的冈比亚儿童呼吸速率的特定年龄参考曲线.
- 确定影响呼吸速率的因素,包括年龄,营养状况和环境条件.
- 建议为5岁以上儿童的呼吸率升高提出一个新的切断值.
主要方法:
- 在两个雨季期间,对冈比亚农村儿童的呼吸速率进行纵向监测.
- 利用了通用添加模型来构建参考曲线和线性混合效应模型来识别影响因素.
- 从6个月至14岁的830名儿童收集了67512个RR测量结果.
主要成果:
- 开发了1至13岁儿童的RR参考曲线.
- 确定年龄,发育迟缓,环境温度和测量时间作为RR的独立预测因素.
- 建议在5岁以上的儿童中提高RR的截止值>26次/分钟.
- 在有疾病迹象的儿童中,在重复测量时观察到较大的RR变异性.
结论:
- 这项研究弥补了热带地区老年儿童呼吸率的关键数据缺口.
- 虽然环境和营养因素影响RR,但它们的影响不足以改变当前的世卫组织指南.
- 患病儿童的RR变异性增加表明,单次测量可能不足以进行可靠的评估,强调在诊断疾病时需要仔细评估.
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