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多发性硬化症认知表型的分类:为期一年的纵向研究
Jessica Podda1, Federica Di Antonio2, Andrea Tacchino2
1Scientific Research Area, Italian Multiple Sclerosis Foundation, Via Operai 40, 16149, Genoa, Italy. jessica.podda@aism.it.
Scientific reports
|September 2, 2024
概括
在多发性硬化症 (MS) 中识别认知表型有助于管理症状. 在患有多发性硬化症 (PwMS) 的人群中,这些独特的认知特征在一年内保持稳定,有助于个性化治疗.
科学领域:
- 神经学 神经学
- 神经心理学 神经心理学
- 康复科学 康复科学 康复科学
背景情况:
- 认知障碍 (CI) 是患有多发性硬化症 (PwMS) 的人面临的重大挑战.
- 了解认知表型对于定制的症状管理和康复策略至关重要.
- 随着时间的推移,监测认知变化可以揭示MS认知衰退的轨迹.
研究的目的:
- 识别和描述MS (PwMS) 患者的不同认知表型.
- 评估这些认知表型在一年时间内的稳定性.
- 评估患者报告结果 (PRO) 和临床医生评估结果 (CAO) 在定义认知表型的临床实用性.
主要方法:
- 利用PRO和CAO的认知和情绪数据将PwMS分为子组.
- 根据认知困难的严重程度和模式,确定了四种不同的认知表型.
- 在一年的随访期内监测这些表型,以评估变化.
主要成果:
- 确定了四种认知表型:保持认知 (44.5%),轻度障碍与注意力问题 (22.8%),明显的多领域障碍 (24.3%),以及严重的多领域障碍与情绪障碍 (8.4%).
- 认知表型在一年的随访期间表现出相对稳定,损伤的类型或数量变化最小.
- 在划分认知表型和理解MS认知衰退方面,PRO和CAO证明是有价值的.
结论:
- 在PwMS的认知表型在一年的时间框架内相对稳定.
- 认知表型的识别和监测为MS认知障碍提供了有价值的见解.
- 将PRO和CAO纳入临床实践可以增强决策和个性化PwMS治疗计划.
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