在毒素基因组学方面的进展,以保护人类健康
Matthew J Meier1, Joshua Harrill2, Kamin Johnson3
1Environmental Health Science and Research Bureau, Health Canada, Ottawa, Ontario, Canada.
Nature reviews. Genetics
|September 2, 2024
概括
毒基因组学使用分子数据,特别是转录组学,来预测暴露的毒性影响. 转录组学方面的进步正在改变人类健康保护的毒理学测试和风险评估.
科学领域:
- 毒理学和分子生物学
- 环境健康和药理学
背景情况:
- 毒素基因组学整合了分子数据 (转录,蛋白质,代谢物,表观基因组学) 来评估毒素效应.
- 转录组学在现代毒理学中至关重要,它提供了可扩展的机械和定量基因表达见解.
研究的目的:
- 自毒基因组学开始以来,审查转录组学在毒理学测试中的应用.
- 突出突出改变毒理风险评估的进展.
主要方法:
- 利用转录生物标志物,网络推断,模式匹配和人工智能来预测危险.
- 使用高通量剂量反应建模与毒基因组数据.
- 利用单细胞转录组学和多细胞组学来获得详细的毒理机制见解.
主要成果:
- 转录组学为毒理学提供规模化的机械和定量数据.
- 毒基因组数据有助于预测危险并保护人类健康.
- 新兴的方法提供了对毒理学机制的详细见解.
结论:
- 转录组学是推动毒理学和风险评估的关键工具.
- 毒基因组学,特别是转录组学,正在彻底改变危害识别和人类健康保护.
- 在多主题和高通量方法方面的持续创新将进一步加强毒理学评估.
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