空气污染:痴呆症的一个潜在的关键驱动力
Mahdiyeh Mohammadzadeh1,2, Amir Hossein Khoshakhlagh3, Jordan Grafman4
1Department of Health in Emergencies and Disasters, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
BMC public health
|September 2, 2024
概括
长期暴露于空气污染,特别是PM2.5和NO2,与认知衰退和痴呆症有关. 减少空气污染是对大脑健康的关键预防措施.
科学领域:
- 环境健康 环境健康
- 神经科学是一个神经科学.
- 流行病学 流行病学
背景情况:
- 空气污染对认知功能和痴呆症的影响得到了广泛的研究,但产生了矛盾的结果.
- 了解空气污染物和痴呆症之间的确切关系对于公共卫生至关重要.
- 之前的研究已经探索了各种方面,需要进行全面的审查.
研究的目的:
- 系统地审查和澄清暴露在空气污染物和患痴呆症的风险之间的关联.
- 综合人类研究中的证据,研究特定空气污染物对认知功能和痴呆症的影响.
- 确定关键的污染物涉及神经退行过程和痴呆症的发展.
主要方法:
- 在Scopus,PubMed和Web of Science数据库中进行系统的文献搜索,直到2023年5月.
- 基于PECO声明的纳入标准;不包括动物,实验室,综述和非痴呆重点研究.
- 使用Joanna Briggs Institute (JBI) 检查清单进行质量评估;审查侧重于阿尔茨海默氏症和非阿尔茨海默氏症痴呆症.
主要成果:
- 在14924个初始记录中,选出了53个符合条件的文章.
- 长期暴露于高水平空气污染物与不良认知影响和痴呆风险增加有关.
- 颗粒物 (PM2.5) 和二氧化 (NO2) 与脑损伤和神经退行症有很强的关联.
结论:
- 空气污染,特别是PM2.5和NO2,是痴呆症的重要危险因素.
- 早期发生的大脑变化强调了长期暴露评估的重要性.
- 减少空气污染和个人暴露是保持大脑健康和减轻痴呆风险的建议预防策略.
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