生命必需8和事件高血压的10年轨迹:基于社区的队列研究
Jiwen Zhong1, Jinguo Jiang2, Liang Guo3,4
1Department of Critical Care Medicine, Zhuhai People's Hospital (Zhuhai Clinical Medical College of Jinan University), Zhuhai, 51900, Guangdong, China.
Lipids in health and disease
|September 2, 2024
概括
随着时间的推移,提高生活必需品8 (LE8) 评分可以显著降低高血压风险. 即使是从较低的LE8分数开始的人也可以从改善中受益,证明它对抗高血压的保护作用.
科学领域:
- 心血管健康 心血管健康
- 公共卫生 公共卫生
- 预防医学 预防医学
背景情况:
- 生活必需品8 (LE8) 和慢性疾病之间的关联是已知的,但其与高血压发病率的具体联系需要调查.
- 了解LE8对高血压的影响对于制定有针对性的预防策略至关重要.
研究的目的:
- 检查生活必需8 (LE8) 评分的10年轨迹与随后的高血压发病率之间的关系.
- 为了确定与发展高血压的不同风险相关的特定LE8得分模式.
主要方法:
- 潜在混合模型从2006年到2016年确定了五个不同的LE8得分轨迹.
- 事件高血压通过临床诊断和身体检查在2016年至2020年期间确定.
- 考克斯模型评估了LE8轨迹与高血压的关联,调整了hs-CRP,年龄,性别,收入,教育和职业等混因素.
主要成果:
- 在7500名参与者中,确定了5个LE8轨迹,在四年随访期间观察到667个高血压事件.
- 与低稳定LE8轨迹相比,中度增加 (HR 0.51),中度减少 (HR 0.81),中度稳定 (HR 0.45) 和高稳定 (HR 0.23) 轨迹显示高血压风险显著降低.
- 一个一致的趋势表明,改善LE8状态与降低发生性高血压风险相关,这种趋势得到了敏感性分析的强有力的证实.
结论:
- 生命的基本8 (LE8) 评分轨迹与高血压发病率有显著的相关性.
- 随着时间的推移,LE8得分有所改善的个体经历了患高血压的风险降低,无论他们的初始得分如何.
- 促进LE8得分的提高提供了预防高血压的可行策略.
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