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Updated: Jun 14, 2025

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这种mTOR路径控制了BRAF在T401的酸化

Daniel Christen1,2,3, Manuel Lauinger1,2, Melanie Brunner4

  • 1Institute of Molecular Medicine, University of Freiburg, Stefan-Meier-Str. 17, 79104, Freiburg, Germany.

Cell communication and signaling : CCS
|September 2, 2024
PubMed
概括

猛素 (mTOR) 信号传递的哺乳动物标,而不是ERK,在T401驱动BRAF酸化. 像torin1和dactolisib这样的mTOR抑制剂抑制了这种酸化,揭示了癌症中BRAF信号的新调节轴.

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