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Updated: Jun 14, 2025

Isolation and Kv Channel Recordings in Murine Atrial and Ventricular Cardiomyocytes
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在PKA和PIAS3之间的交叉调节心脏Kv4通道SUMOylation

Leslie-Anne R Jansen1, Meghyn A Welch1,2, Leigh D Plant3

  • 1Department of Biology, Georgia State University, Atlanta, GA, USA.

Cell communication and signaling : CCS
|September 2, 2024
PubMed
概括

蛋白质SUMOylation调节了离子通道的功能. 这项研究确定PIAS3是Kv4.2和HCN2通道的SUMO E3结合酶,控制它们的表面表达和对PKA酸化的反应.

关键词:
一个心肌细胞.离子通道回收利用在 PIAS3 中.后翻译修改后的修改.蛋白激酶A是一种蛋白质激酶.

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