多重氧的血度和结肠直肠腺瘤的风险
Michael N Passarelli1, Jeffrey G McDonald2,3, Bonne M Thompson2,3
1Department of Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire.
Cancer prevention research (Philadelphia, Pa.)
|September 2, 2024
概括
一些高水平的氧化醇,胆固醇代谢物,与增加结直肠腺瘤风险有关,而其他可能是保护性的. 这些发现表明,氧醇可能是预防结肠直肠癌的目标.
科学领域:
- 生物化学 生物化学
- 在瘤学瘤学.
- 预防医学 预防医学
背景情况:
- 氧醇,胆固醇代谢物,在调节胆固醇,脂肪酸和葡萄糖平衡中起作用.
- 循环中的氧醇通过酶过程或氧化应激在整个身体中产生.
- 以前的研究表明,27-胆固醇 (27-OHC) 是结直肠腺瘤的潜在危险因素.
研究的目的:
- 调查多种循环氧与结直肠腺瘤风险的关联.
- 评估27-胆固醇 (27-OHC),25-胆固醇,24-S-胆固醇,7ɑ-胆固醇和4β-胆固醇与腺瘤风险相关的情况.
- 评估27-OHC与其他氧醇存在的晚期腺瘤风险的持续关联.
主要方法:
- 分析了维生素D/聚合物预防研究的1246名参与者的血样本.
- 液体染色学/质谱学被用来测量五种循环氧醇的度.
- 逻辑线性回归和贝叶斯内核机器回归模型被用来分析关联,调整混因素.
主要成果:
- 高水平的7α-基胆固醇与结直肠腺瘤的风险增加有关 (RR, 1.22).
- 相反,较高的4β-基胆固醇度与这些息肉的风险降低有关 (RR,0.84).
- 之前观察到的27-OHC与晚期腺瘤风险之间的关联在对其他氧化进行控制后仍然显著 (RR, 1.26).
结论:
- 在初始腺瘤诊断时循环中的氧醇度可以预测随后的结肠直肠病变的发生率.
- 像7α-基胆固醇和4β-基胆固醇这样的特定氧化醇显示出与腺瘤风险的差异关联.
- 向氧胆固醇形成为预防结直肠癌提供了一个潜在的新战略.
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