提高了离子交叉连接的硫化凝膜的粘膜粘合性能
Ankita Modi1, Reshma Sanal1, Ashika Suresh1
1Division of Dental Products, Department of Biomaterial Science and Technology, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, India.
Journal of biomaterials science. Polymer edition
|September 3, 2024
概括
研究人员开发了一种新型的粘膜粘合内层,使用硫化凝为口服药物输送带. 这种增强的粘膜粘合改善了在动态的口腔环境中药物保留.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 药物输送系统 药物输送系统
背景情况:
- 局部口服药物递送由于口腔环境的动态而带来挑战,阻碍了药物保留.
- 开发有效的粘膜材料对于口腔中药物持续释放至关重要.
研究的目的:
- 使用凝膠膠 (GG) 設計粘性內層為三層口服藥物輸送帶.
- 通过化和离子交叉链接来增强凝膠的粘膜粘合性,以改善口服药物保留.
主要方法:
- 格兰 (GG) 经过碳胺化学修改了L-氨酸,以引入醇组.
- 用氨酸硫酸盐进行了离子交叉连接,以酸为基的凝溶液.
- 用溶剂造制备了片,并评估了它们的厚度,粘合力 (猪口粘膜),抗拉强度和膨胀能力.
主要成果:
- 与赤裸的GG薄膜相比,化凝膜 (GG 1S,GG 2S) 的厚度显著降低.
- 在猪口腔粘膜上,用硫化凝乳 (GG 2S) 实现了高粘合力 (10 N.mm).
- 化凝膜表现出良好的机械性能 (拉伸强度~48.2 MPa),细胞相容性和膨胀能力.
结论:
- 离子交叉连接的硫化凝膜具有出色的粘粘性和机械强度.
- 这些硫化凝膜适合作为口服药物输送带的内粘膜层使用.
- 开发的材料为克服局部口服药物输送中的药物保留挑战提供了一个有希望的解决方案.
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