准肠道微生物组以改善免疫治疗结果:一篇评论
Adi David1, Shaked Lev-Ari2,3
1Tal Center for Integrative Medicine, Institute of Oncology, Sheba Medical Center, Ramat-Gan, Israel.
Integrative cancer therapies
|September 3, 2024
概括
饮食干预可以优化肠道微生物群 (您的消化系统中的微生物群落),以提高抗癌免疫疗法的有效性. 定制营养可以提高治疗结果,减少副作用.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
背景情况:
- 癌症免疫疗法已经彻底改变了治疗方法,但面临着抗性和免疫相关不良事件 (irAEs) 的挑战.
- 瘤微环境 (TME) 显著影响免疫疗法耐药性.
- 肠道微生物组在调节免疫反应和治疗结果方面发挥着至关重要的作用.
研究的目的:
- 探索肠道微生物组在饮食-微生物群-免疫 (DMI) 三方中的作用.
- 了解如何饮食干预可以提高抗癌免疫疗法的疗效.
- 确定操纵肠道微生物群的策略,以改善癌症治疗.
主要方法:
- 这篇叙事综述综合了关于肠道微生物组,饮食和癌症免疫治疗的现有研究.
- 它检查了饮食模式,营养成分和干预措施对TME和肠道微生物群的影响.
- 该评论讨论了抗生素对肠道微生物群多样性和免疫治疗疗效的影响.
主要成果:
- 饮食模式 (例如,地中海饮食) 和营养成分可以积极影响TME和肠道微生物群.
- 肠道微生物组调节对于增强抗癌免疫疗法至关重要.
- 抗生素可能通过破坏肠道微生物群而对免疫疗法的有效性产生负面影响.
结论:
- 需要量身定制的营养策略来优化微生物群落,以加强癌症患者的免疫调节.
- 操纵肠道微生物组有望改善免疫治疗的可访问性并最大限度地减少副作用.
- 对饮食干预措施的进一步研究对于个性化癌症护理和改善治疗结果至关重要.
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