揭露沉默的威胁:COVID-19对脏移植的普遍影响
B Handan Özdemir1, Alev Ok Atılgan, Aydan Akyüz Özdemir
1>From the Pathology Department, Faculty of Medicine, Baskent University, Ankara, Türkiye.
概括
COVID-19显著影响移植接受者,导致急性损伤和增加移植损失. 组织病理学发现显示出广泛的损伤,强调需要密切监测和管理.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 病毒学 病毒学
- 移植免疫学 移植免疫学
背景情况:
- 众所周知,COVID-19会影响功能,有记录的蛋白尿和急性损伤病例.
- 在COVID-19患者中对脏异种移植活检的综合性组织病理学分析仍然有限.
研究的目的:
- 评估感染COVID-19的移植受体的组织病理特征和临床结果.
- 在这个患者队列中,确定与急性损伤和移植损失相关的因素.
主要方法:
- 对17名患有COVID-19的脏移植接受者的回顾性评估.
- 临床数据的分析,脏全移植活检的发现,以及患者的结局.
主要成果:
- 35.3%的患者患有急性损伤,需要血液透析,与COVID-19严重程度相关 (肺炎,住院).
- 观察到显著的蛋白尿症 (82.4%),新发性血尿症 (35.3%) 和性综合征 (58.8%).
- 管状病毒包容性变化 (47.1%) 和各种形式的血球炎,包括焦点细分血球样硬化,是普遍存在的,与移植损失的风险增加相关 (75%).
- 88.2%的人在COVID-19后经历了排斥,其中46.7%导致了移植损失.
结论:
- COVID-19对脏全移植产生了多方面的和持久的有害影响.
- 细致的监测和量身定制的管理对于减轻COVID-19脏移植接受者严重脏并发症和移植损失至关重要.
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