[心脏门手术后手术后 Delirium 的白细胞衍生标记的预测值]
Xintian Zhang1, Yanhu Ge, Dongni Zhang
1Department of Anesthesiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China. Corresponding author: Ma Jun,
Zhonghua wei zhong bing ji jiu yi xue
|September 3, 2024
概括
白细胞衍生标记物,包括中性粒细胞与淋巴细胞的比率 (NLR) 和血小板与白细胞的比率 (PWR) 的差异,在心脏门手术患者中显示出预测术后痴呆症 (POD) 的潜力.
科学领域:
- 心血管外科心血管外科
- 关键护理医学 关键护理医学
- 血液学 血液学 血液学
背景情况:
- 手术后痴呆症 (POD) 是心脏门手术后的常见并发症,与不良结果相关.
- 确定POD可靠的预测因子对于及时干预和改善患者管理至关重要.
研究的目的:
- 调查白细胞衍生标记物的预测价值,特别是中性粒细胞与淋巴细胞的比率 (NLR) 和血小板与白细胞的比率 (PWR),用于心脏门手术患者的POD发展.
主要方法:
- 一项前性队列研究招募了235名接受心脏门手术的患者.
- 计算了术前和术后的NLR和PWR. 使用多变量逻辑回归和ROC曲线分析来识别预测因素并评估POD预测模型.
主要成果:
- 与非妄想症组相比,POD组 (35.32%) 的查尔森并发症指数 (CCI) 和迷你精神状态检查 (MMSE) 得分较高,较低.
- 在狂妄症小组中,NLR和PWR的差异明显高于狂妄症小组.
- 该POD预测模型,结合CCI,外科手术期间心房动,心肺绕道持续时间,ICU停留,NLR差异和PWR差异,实现了AUC为0.805.
结论:
- 在心脏门手术后,NLR和PWR的变化与POD独立相关.
- 这些白细胞衍生的标记物显示出潜在的作为预测POD风险的有价值工具.
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